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Xianglong Hu
Researcher at South China Normal University
Publications - 63
Citations - 5107
Xianglong Hu is an academic researcher from South China Normal University. The author has contributed to research in topics: Micelle & Nanocarriers. The author has an hindex of 34, co-authored 55 publications receiving 3802 citations. Previous affiliations of Xianglong Hu include University of Science and Technology of China & Hong Kong University of Science and Technology.
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Journal ArticleDOI
Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking, and Drug Delivery
TL;DR: It is demonstrated that PEG-b-PCPTM polyprodrug amphiphiles, where PEG is poly(ethylene glycol) and PCPTM is polymerized block of reduction-cleavable camptothecin (CPT) prodrug monomer, can self-assemble into four types of uniform nanostructures including spheres, large compound vesicles, smooth disks, and unprecedented staggered lamellae with spiked periphery.
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Cell-penetrating hyperbranched polyprodrug amphiphiles for synergistic reductive milieu-triggered drug release and enhanced magnetic resonance signals.
TL;DR: The hyperbranched chain topology provides a novel theranostic polyprodrug platform for synergistic imaging/chemotherapy and enhanced tumor uptake and hyperbrANChed cores conjugated with reduction-activatable camptothecin prodrugs and magnetic resonance (MR) imaging contrast agent.
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Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation
Dong Wang,Dong Wang,Huifang Su,Ryan T. K. Kwok,Xianglong Hu,Xianglong Hu,Hang Zou,Qianxin Luo,Michelle M. S. Lee,Wenhan Xu,Jacky W. Y. Lam,Ben Zhong Tang +11 more
TL;DR: The first water-soluble NIR AIEgen was synthesized and used for ultrafast wash-free cellular imaging and photodynamic cancer cell ablation.
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Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy.
TL;DR: N nanoparticles that release camptothecin in a reactive oxygen species dependent manner, leading to cancer cell death, are used, which overcomes the short lifespan and action range of ROS, avoids the penetration limitation of exogenous light in photodynamic therapy, and is promising for theranostics.
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Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes
Ji Qi,Chao Chen,Xiaoyan Zhang,Xianglong Hu,Shenglu Ji,Ryan T. K. Kwok,Jacky Wing Yip Lam,Dan Ding,Ben Zhong Tang,Ben Zhong Tang +9 more
TL;DR: A smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy to ensure total tumour removal.