Z
Zhiyuan Zhong
Researcher at Soochow University (Suzhou)
Publications - 359
Citations - 26501
Zhiyuan Zhong is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Medicine & Micelle. The author has an hindex of 76, co-authored 325 publications receiving 23337 citations. Previous affiliations of Zhiyuan Zhong include Ludwig Maximilian University of Munich & Academia Sinica.
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Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release.
TL;DR: Novel acid degradable poly(acetal urethane) (PAU) and corresponding triblock copolymer micelles for pH-triggered intracellular delivery of a model lipophilic anticancer drug, doxorubicin (DOX) are reported.
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EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo
Jing Chen,Jia Ouyang,Qijun Chen,Chao Deng,Fenghua Meng,Jian Zhang,Ru Cheng,Qing Lan,Zhiyuan Zhong +8 more
TL;DR: It is reported that epidermal growth factor receptor (EGFR) and CD44 dual-targeted multifunctional hyaluronic acid nanogels ( EGFR/CD44-NGs) boost protein delivery to ovarian and breast cancers in vitro and in vivo.
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Branched polyethylenimine derivatives with reductively cleavable periphery for safe and efficient in vitro gene transfer.
TL;DR: The modification of PEI with reductively cleavable cystamine periphery appears to be a potential approach to develop safer and more efficient nonviral gene vectors.
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Functional Poly(ε-caprolactone)s via Copolymerization of ε-Caprolactone and Pyridyl Disulfide-Containing Cyclic Carbonate: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer Micelles
Wei Chen,Wei Chen,Yan Zou,Junna Jia,Fenghua Meng,Ru Cheng,Chao Deng,Jan Feijen,Jan Feijen,Zhiyuan Zhong +9 more
TL;DR: This study presents a versatile and controlled synthesis of PDS-functionalized biodegradable polymers and reduction-sensitive biodesgradable graft copolymer micelles that are of particular interest for active intracellular drug release.
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Unprecedented Access to Functional Biodegradable Polymers and Coatings
TL;DR: Results of contact angle measurements, X-ray photoelectron spectroscopy (XPS), and fluorescence studies showed that biodegradable coatings based on these VS-functionalized polymers allowed direct, efficient, and clean surfacefunctionalization with thiol-containing molecules in aqueous conditions, which is unprecedented and opens a new avenue to surface functionalization of medical implants as well as cell and tissue scaffolds.