Z
Zhiyuan Zhong
Researcher at Soochow University (Suzhou)
Publications - 359
Citations - 26501
Zhiyuan Zhong is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Medicine & Micelle. The author has an hindex of 76, co-authored 325 publications receiving 23337 citations. Previous affiliations of Zhiyuan Zhong include Ludwig Maximilian University of Munich & Academia Sinica.
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Journal ArticleDOI
Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof-of-Concept Studies
Imke A. B. Pijpers,Loai K. E. A. Abdelmohsen,Yifeng Xia,Shoupeng Cao,David S. Williams,Fenghua Meng,Jan C. M. van Hest,Zhiyuan Zhong +7 more
TL;DR: Adapt morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles are discussed.
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Dual bio-responsive gene delivery via reducible poly(amido amine) and survivin-inducible plasmid DNA
Ran Namgung,Jonathan H. Brumbach,Ji Hoon Jeong,James W. Yockman,Sung Wan Kim,C. Lin,Zhiyuan Zhong,Jan Feijen,Johan F.J. Engbersen,Won Jong Kim +9 more
TL;DR: A dual bio-responsive gene delivery system was developed by using bioreducible p(ABOL) for enhanced intracellular gene delivery and survivin-inducible gene expression system (pSur-sFlt-1 or pSUR-Luc reporter gene) that demonstrates increased gene expression in cancer that has advantages over current gene delivery systems.
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HER2-Specific Reduction-Sensitive Immunopolymersomes with High Loading of Epirubicin for Targeted Treatment of Ovarian Tumor.
Lin Ding,Wenxing Gu,Wenxing Gu,Yifan Zhang,Shujing Yue,Huanli Sun,Jeroen J. L. M. Cornelissen,Zhiyuan Zhong +7 more
TL;DR: In vitro studies revealed that Trastuzumab-decorated disulfide-crosslinked polymersomes (Tra-Ps) with long-term storage stability could rapidly release drugs under a reductive condition and efficiently deliver large amount of EPI•HCl to HER2-positive SKOV-3 cells, leading to stronger cytotoxicity than the non-targeted Ps-EPI.
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Protein release from injectable stereocomplexed hydrogels based on PEG–PDLA and PEG–PLLA star block copolymers
Christine Hiemstra,Zhiyuan Zhong,S.R. van Tomme,Wim E. Hennink,Pieter J. Dijkstra,Jan Feijen +5 more
TL;DR: The release of two model proteins, lysozyme and immunoglobulin G (IgG) from injectable, fast gelling, biodegradable hydrogels composed of PEG–PLLA and PEG-PDLA star block copolymers was investigated.