Z
Zhong Chen
Researcher at King's College London
Publications - 58
Citations - 1811
Zhong Chen is an academic researcher from King's College London. The author has contributed to research in topics: Cardiac resynchronization therapy & Heart failure. The author has an hindex of 19, co-authored 52 publications receiving 1554 citations. Previous affiliations of Zhong Chen include University of Cambridge & Center for Excellence in Education.
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Journal ArticleDOI
Left ventricular endocardial pacing is less arrhythmogenic than conventional epicardial pacing when pacing in proximity to scar.
Caroline Mendonca Costa,Aurel Neic,Karli Gillette,Bradley Porter,Justin Gould,Baldeep S. Sidhu,Zhong Chen,Mark K. Elliott,Vishal Mehta,Gernot Plank,Christopher A. Rinaldi,Christopher A. Rinaldi,Martin J. Bishop,Steven A. Niederer +13 more
TL;DR: Endocardial pacing is less arrhythmogenic than epicardial pacing when pacing proximal to scar and is less susceptible to pacing location relative to scar.
Journal ArticleDOI
Left ventricular epicardial electrograms show divergent changes in action potential duration in responders and nonresponders to cardiac resynchronization therapy.
Zhong Chen,Ben Hanson,Manav Sohal,Eva Sammut,Nicholas Child,Anoop Shetty,Ryan Boucher,Julian Bostock,Jaswinder Gill,Gerald Carr-White,C. Aldo Rinaldi,Peter Taggart +11 more
TL;DR: In patients with heart failure, LV epicardial APD (activation recovery interval) altered during CRT, which may provide an explanation for the persistent high incidence of arrhythmias in some patients with CRT and the additional mortality benefit observed in responders of CRT.
Journal ArticleDOI
Glycosylation of glycopeptides: a comparison of chemoenzymatic and chemical methods
Catherine Leimkuhler,Zhong Chen,Ryan G. Kruger,Markus Oberthür,Markus Oberthür,Wei Lu,Christopher T. Walsh,Daniel Kahne,Daniel Kahne +8 more
TL;DR: The efficiency of chemical and enzymatic methods for glycosylation of glycopeptides related to vancomycin are compared and the parameters that should be considered in designing synthetic approaches to Glycosylated natural product derivatives are described.
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Current concepts relating coronary flow, myocardial perfusion and metabolism in left bundle branch block and cardiac resynchronisation therapy.
Simon Claridge,Simon Claridge,Zhong Chen,Tom Jackson,Eva Sammut,Manav Sohal,Jonathan M. Behar,Jonathan M. Behar,Reza Razavi,Steven A. Niederer,Christopher A. Rinaldi,Christopher A. Rinaldi +11 more
TL;DR: There remains a need for further research to clarify the interaction of coronary flow with perfusion and metabolism in patients who undergo CRT, as CRT appears to improve homogeneity in myocardial perfusion.
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Lower incidence of inappropriate shock therapy in patients with combined cardiac resynchronisation therapy defibrillators (CRT-D) compared with patients with non-CRT defibrillators (ICDs).
Zhong Chen,Tushar Kotecha,Siobhan Crichton,Anoop Shetty,Manav Sohal,Aruna Arujuna,Senthil Kirubakaran,Julian Bostock,Michael Cooklin,Mark D O'Neill,Matthew Wright,Jaswinder Gill,Christopher A. Rinaldi +12 more
TL;DR: An increasing number of patients with advanced heart failure receive combined ICD and cardiac resynchronisation therapy devices (CRT‐D) and a significant number experience inappropriate shock therapy from implantable cardioverter‐defibrillators.