Zhong-Mei Zou

TL;DR: Results showed that the gut microbiota was altered in association with fecal metabolism in depressive conditions, and suggest that the 16S rRNA gene sequencing and LC–MS based metabolomics approach can be further applied to assess pathogenesis of depression.

TL;DR: It was observed that metabolic perturbations induced by chronic variable stress were restored in a time-dependent pattern after treatment with CSGS, which suggested that the therapeutic effect of CSGS on depression may involve in regulating the dysfunctions of energy metabolism, tryptophan metabolism, bone loss and liver detoxification.

TL;DR: This is the first report on the comprehensive determination of chemical constituents in XKS preparations by LC-LTQ-Orbitrap mass spectrometry, suggesting that the established methods would be a powerful and reliable analytical tool for the characterization of multi-constituent in complex chemical system and quality control of TCM preparations.

TL;DR: Investigating the gut microbiome and metabolomes of cecal contents in the isoproterenol-induced acute myocardial ischemia (AMI) rats revealed the potential link of these altered gut microbiota/metabolomes and intestinal inflammatory factors and apoptotic proteins and further confirmed their intimate connections with intestinal inflammation and gut barrier.

TL;DR: A tissue targeted metabonomic study using an integrated approach of ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and proton nuclear magnetic resonance (1H NMR) provided a unique perspective on localized metabolic information of ISO induced-MI, which gave new insights into the pathogenesis of MI, discovery of targets for clinical diagnosis and treatment.