Showing papers in "Journal of Pharmaceutical and Biomedical Analysis in 2017"

TL;DR: Results showed that the gut microbiota was altered in association with fecal metabolism in depressive conditions, and suggest that the 16S rRNA gene sequencing and LC–MS based metabolomics approach can be further applied to assess pathogenesis of depression.

TL;DR: A new HPLC method for non‐psychoactive cannabinoids analysis in hemp was proposed and demonstrated to be a very useful tool for the analysis of cannabinoids in both the plant material and its derivatives for pharmaceutical and nutraceutical applications.

TL;DR: The tuneability of DESs as tailor‐made solvents to efficiently extract polar and non‐polar bioactive compounds from Platycladi Cacumen was detailedly investigated and it was demonstrated that the extractability of both flavonoid glycosides and aglycones was greater with certain designed DESs than conventionalsolvents.

TL;DR: The present study suggests that DESs are truly designer and efficient solvents and the method developed was efficient and sustainable for extraction main compounds from Fig leaves.

TL;DR: It was possible to detect pharmaceuticals in all the aqueous environmental matrices considered, including in bottled water at concentrations up to 31 ng L−1 (salicylic acid), and non‐steroidal anti‐inflammatory drugs/analgesics was the therapeutic group most frequently detected.

TL;DR: The optimized method for the quantitative determination of various cannabinoids in cannabis plant material using high pressure liquid chromatography (HPLC) with a diode array detector (DAD) was validated for specificity, linearity, sensitivity, precision, accuracy, and stability.

TL;DR: The objective of this review is to give an overview of past, current and emerging trends in 2D‐LC techniques applied to pharmaceutical compounds to predict future advances in two‐dimensional separation techniqes for pharmaceutical analysis.

TL;DR: A multi‐class method for the determination of 24 emerging pharmaceutical residues has been developed and validated and a single‐laboratory validation procedure showed satisfactory analytical performance.

TL;DR: The results suggest that tissue‐specific metabolites profiling dynamically changed in process of ginsenosides biosynthesis, which may offer a new train of thoughts to the mechanisms of the ginsene biosynthesis at the metabolite level.

TL;DR: The results obtained indicates that the proposed method is more efficient than QuEChERS, and was applied to monitoring these compounds along the Turia River.

TL;DR: VAMS was successfully applied for the first time to the therapeutic drug monitoring of HCQ in rheumatoid arthritis patients and established that VAMS is a simple and accurate sampling technique that delivers the benefits of DBS sampling while overcoming the issues associated with hematocrit and homogeneity.

TL;DR: This novel method for the quantitative measurement of gut microbial‐derived short‐chain fatty acids (SCFAs) in human infant stool has been developed and validated and is applicable to future studies that investigate the biological roles of SCFAs in paediatric health and diseases.

TL;DR: Results indicate a novel metabolite, an isomer of the pentanoic acid metabolite and a slow terminal elimination of JWH‐018 and all metabolites, which may lead to accumulation in chronic users.

TL;DR: The results demonstrated that flavonoids and furofuran lignans were the major constituents in Z. armatum leaves, and two rapid and simple ultra performance liquid chromatography‐diode array detection methods were developed for the simultaneous quantitative determination of isolated compounds.

TL;DR: Volumetric absorptive microsampling (VAMS) method validated for miltefosine quantification in human blood with good performance in terms of linearity, selectivity, accuracy, recovery, carry‐over and matrix effect.

TL;DR: The developed and validated method was applied for the simultaneous determination of 12 lignans in rat plasma after administered with wine processed Schisandra Chinensis fructus (WPSCF) extract and was found capable of providing extensive pharmacokinetic profiles of multi‐components absorbed into blood after oral administrated with WPSCF extract.

TL;DR: The combining use of the T‐NP method could discover potential drug targets and disclose the biological processes of WTD, which will open up a new approach in the study of TCM in future.

TL;DR: The presented method is a rapid and simple option for routine TDM of piperacillin, meropenem, ceftazidime and flucloxacillin in human plasma without extensive sample preparation and using common equipment, which is of advantage regarding time and consumables.

TL;DR: Investigation and compare the metabolism of six methylenedioxy derivatives and two bioisosteric analogues using pooled human liver microsomes combined with cytosol (pHLC) or pooledhuman liver S9 fraction (pS9) all after addition of co‐substrates for six phase I and II reactions.

TL;DR: A comprehensive research of P. multiflorum was showed, which could provide a meaningful basis for further quality control, pharmacological as well as toxicological researches and the pharmacokinetic studies of some major compounds in blood were investigated by using ultra performance liquid chromatography with tandem mass spectrometry method.

TL;DR: The importance of binding of anticancer drug to AAG spatially in the diseases like cancers where the plasma concentration of AAG increases many folds is suggested to be adjusted accordingly to achieve optimal treatment outcome.

TL;DR: VAMS is a valid alternative sampling strategy for the quantification of antibiotics and is valuable in support of clinical PK/PD studies and consequently therapeutic drug monitoring (TDM) in pediatrics.

TL;DR: Grinding as eco‐friendly method to improve the praziquantel solubility was proposed and confirmed that the co‐grinding with the proper additive is as a promising strategy to improve biopharmaceutical properties of the drug.

TL;DR: The method showed that SFC could be employed as a useful tool for the quality assessment of Traditional Chinese medicines (TCMs) containing flavonoids as active components by providing separations that were about three times faster than with a previously developed HPLC method.

TL;DR: An assay method to quantify tacrolimus from 1 to 250 ng/mL in whole blood was qualified by ensuring that linearity, selectivity, intra‐ and inter‐batch reproducibility, and stability were within the acceptance criteria.

TL;DR: Almost 3–4 fold increase in solubility and dissolution profile of cocrystals was observed which was further corroborated by improved in vitro and in vivo activities including antioxidant, antihaemolytic and anti‐inflammatory thus, opening a new viable technique for the exploitation of useful phytonutrients.

TL;DR: The novel Q‐Orbitrap mass spectrometry has been proved to be a very promising and powerful tool for routine screening of bioactive compounds in traditional Chinese medicine injection, ensuring drug safety and public health.

TL;DR: Various promising strategies including novel packaging materials, cryogenic storage and advanced technology for formulation development can serve the purpose of extension of space medicine's stability.

TL;DR: The SFC method proposed in this study could be presented as a suitable fast alternative to EP LC method for the quantitative determination of salbutamol impurities.

TL;DR: Demethylation, demethylenation, reduction, hydroxylation, and subsequent glucuronidation, sulfation and methylation were the major metabolic pathways of BBR in vivo.