Journal ArticleDOI
Urinary metabonomics study of anti-depressive effect of Chaihu-Shu-Gan-San on an experimental model of depression induced by chronic variable stress in rats.
Zhi-Heng Su,Shu-Qi Li,G. A. Zou,Changyuan Yu,Yan-Guo Sun,Hong-Wu Zhang,Ying Gu,Zhong-Mei Zou +7 more
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TLDR
It was observed that metabolic perturbations induced by chronic variable stress were restored in a time-dependent pattern after treatment with CSGS, which suggested that the therapeutic effect of CSGS on depression may involve in regulating the dysfunctions of energy metabolism, tryptophan metabolism, bone loss and liver detoxification.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2011-06-01. It has received 97 citations till now.read more
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Modern analytical techniques in metabolomics analysis
TL;DR: The combined use of modern instrumental analytical approaches has unravelled the ideal outcomes in metabolomics, and is beneficial to increase the coverage of detected metabolites that can not be achieved by single-analysis techniques.
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Variations in gut microbiota and fecal metabolic phenotype associated with depression by 16S rRNA gene sequencing and LC/MS-based metabolomics.
TL;DR: Results showed that the gut microbiota was altered in association with fecal metabolism in depressive conditions, and suggest that the 16S rRNA gene sequencing and LC–MS based metabolomics approach can be further applied to assess pathogenesis of depression.
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Future Perspectives of Chinese Medical Formulae: Chinmedomics as an Effector
Xijun Wang,Aihua Zhang,Hui Sun +2 more
TL;DR: The scientific study of chinmedomics is at an early stage and requires further scrutiny and validation, but the approach has major implications to improve the efficacy ofchinmediformulae.
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Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future.
Alessandro Buriani,María Laura García-Bermejo,Enrica Bosisio,Qihe Xu,Huige Li,Xuebin Dong,Monique S. J. Simmonds,Maria Carrara,Noelia Tejedor,Javier Lucio-Cazana,Peter J. Hylands +10 more
TL;DR: In this short review, omic applications inTCM research are reviewed which has allowed some speculation regarding future perspectives for these approaches in TCM modernisation and standardisation.
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Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review.
Dandan Feng,Tao Tang,Xiangping Lin,Zhao-yu Yang,Shu Yang,Zian Xia,Yun Wang,Piao Zheng,Yang Wang,Chunhu Zhang +9 more
TL;DR: The current evidence supports the efficacy of CHFs in the treatment of depression, but additional large-scale randomized controlled clinical trials and sophisticated pharmacology studies should be performed.
References
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Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.
TL;DR: Findings support the hypothesis that alterations in 5-HT neurons play a role in the pathophysiology of depression.
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Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
TL;DR: This review focuses on their essential role in maintaining mitochondrial function and on how mitochondria are compromised by a deficiency of any B vitamin.
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NMR-Based Metabolic Profiling and Metabonomic Approaches to Problems in Molecular Toxicology
TL;DR: The main contributions to the development of NMR-based metabonomic and metabolic profiling approaches for toxicological assessment, biomarker discovery, and studies on toxic mechanisms are reviewed.
Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis
D. F. Horrobin,C. N. Bennett +1 more
TL;DR: In this article, several gene candidates for involvement in depression and bipolar disorder are proposed, including Prostaglandins, Leukotrienes and Essential Fatty Acids.
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Metabolomics: towards understanding traditional Chinese medicine.
TL;DR: The development of robust metabolomic platforms will greatly facilitate the understanding of the action mechanisms of TCM formulae and the analysis of Chinese herbal and mineral medicine, acupuncture, and Chinese medicine syndromes.