Z
Zhongchan Sun
Researcher at National Institutes of Health
Publications - 12
Citations - 308
Zhongchan Sun is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 6 publications receiving 269 citations. Previous affiliations of Zhongchan Sun include Fourth Military Medical University.
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Journal ArticleDOI
Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury.
Jie Lu,Jason M. Frerich,L. Christine Turtzo,L. Christine Turtzo,Siqi Li,Jeffrey Chiang,Chunzhang Yang,Xiaoping Wang,Chao Zhang,Chenxi Wu,Zhongchan Sun,Gang Niu,Zhengping Zhuang,Roscoe O. Brady,Xiaoyuan Chen,Xiaoyuan Chen +15 more
TL;DR: The preservation of sufficient expression of nerve growth factor (NGF) and activation of the neurotrophic tyrosine kinase receptor type 1 (TrkA) pathway following HDACi treatment to be crucial in stimulating the survival of CNS cells after TBI is demonstrated.
Journal ArticleDOI
In Vivo Labeling of Serum Albumin for PET
Gang Niu,Lixin Lang,Dale O. Kiesewetter,Ying Ma,Zhongchan Sun,Ning Guo,Jinxia Guo,Chenxi Wu,Xiaoyuan Chen +8 more
TL;DR: The distribution and local accumulation of serum albumin can be noninvasively visualized and quantified by 18F-AlF-NEB and 64Cu- NEB PET and the simple labeling and broad applications make these imaging probes attractive for clinical translation.
Journal ArticleDOI
VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle.
Zhongchan Sun,Zhongchan Sun,Peng Huang,Peng Huang,Guang Tong,Jing Lin,Jing Lin,Albert J. Jin,Pengfei Rong,Lei Zhu,Lei Zhu,Liming Nie,Gang Niu,Feng Cao,Xiaoyuan Chen +14 more
TL;DR: The design and synthesis of multifunctional VEGF-loaded IR800-conjugated graphene oxide (GO-IR800-VEGF) for multi-modality imaging-monitored therapeutic angiogenesis of ischemic muscle suggests the great promise of using graphene oxide in theranostic applications for treating isChemic disease.
Journal ArticleDOI
Comparison of three dimeric 18F-AlF-NOTA-RGD tracers.
Jinxia Guo,Jinxia Guo,Lixin Lang,Shuo Hu,Ning Guo,Lei Zhu,Lei Zhu,Zhongchan Sun,Ying Ma,Dale O. Kiesewetter,Gang Niu,Qingguo Xie,Xiaoyuan Chen +12 more
TL;DR: In this paper, a rapid one-step radiolabeling strategy by the complexation of 18F-aluminum fluoride with NOTA-peptide conjugates was successfully applied to synthesize three dimeric RGD peptides.
Journal ArticleDOI
Development of a New Thiol Site-Specific Prosthetic Group and Its Conjugation with [Cys(40)]-exendin-4 for in Vivo Targeting of Insulinomas
Xuyi Yue,Dale O. Kiesewetter,Jinxia Guo,Jinxia Guo,Zhongchan Sun,Xiao-Xiang Zhang,Lei Zhu,Lei Zhu,Gang Niu,Ying Ma,Lixin Lang,Xiaoyuan Chen +11 more
TL;DR: Positron emission tomography results showed that the new thiol-specific tracer, N-5-[(18)F]FPenM-[cys(40)]-exendin-4, had high tumor uptake and rapid liver and kidney clearance, which was comparable to the imaging results with [(18]F]FBEM-[ cys( 40)]- exend in-4 reported by the group.