Z
Zhengping Zhuang
Researcher at National Institutes of Health
Publications - 370
Citations - 24358
Zhengping Zhuang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Loss of heterozygosity & Germline mutation. The author has an hindex of 70, co-authored 367 publications receiving 22544 citations. Previous affiliations of Zhengping Zhuang include University of Maryland, Baltimore & Beth Israel Deaconess Medical Center.
Papers
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Journal ArticleDOI
Laser Capture Microdissection
Michael R. Emmert-Buck,Robert F. Bonner,Paul D. Smith,Rodrigo F. Chuaqui,Zhengping Zhuang,Seth R. Goldstein,Rhonda A. Weiss,Lance A. Liotta +7 more
TL;DR: Laser capture microdissection under direct microscopic visualization permits rapid one-step procurement of selected human cell populations from a section of complex, heterogeneous tissue.
Journal ArticleDOI
Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1
Settara C. Chandrasekharappa,Siradanahalli C. Guru,Pachiappan Manickam,Shodimu Emmanuel Olufemi,Francis S. Collins,Michael R. Emmert-Buck,Larisa V. Debelenko,Zhengping Zhuang,Irina A. Lubensky,Lance A. Liotta,Judy S. Crabtree,Yingping Wang,Bruce A. Roe,Jane M. Weisemann,Mark S. Boguski,Sunita K. Agarwal,Mary Beth Kester,Young Sik Kim,Christina Heppner,Qihan Dong,Allen M. Spiegel,A. Lee Burns,Stephen J. Marx +22 more
TL;DR: The identification of MEN1 will enable improved understanding of the mechanism of endocrine tumorigenesis and should facilitate early diagnosis of multiple endocrine neoplasia-type 1.
Journal ArticleDOI
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Laura S. Schmidt,Fuh Mei Duh,F. Chen,Takeshi Kishida,Gladys Glenn,Peter L. Choyke,Stephen W. Scherer,Zhengping Zhuang,Irina A. Lubensky,Michael Dean,Rando Allikmets,Abirami Chidambaram,Ulf S.R. Bergerheim,J. T. Feltis,C. Casadevall,A. Zamarron,M. Bernues,Stéphane Richard,C. J. M. Lips,McClellan M. Walther,Lap-Chee Tsui,Laura Geil,Mary Lou Orcutt,Thomas Stackhouse,J. Lipan,L. Slife,Hiltrud Brauch,Jochen Decker,G. Niehans,M. D. Hughson,Holger Moch,Stefan Storkel,Michael I. Lerman,W.M. Linehan,B. Zbar +34 more
TL;DR: The results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas.
Journal ArticleDOI
Neurofibromatosis type 2
Ashok R. Asthagiri,Dilys M. Parry,John A. Butman,H. Jeffrey Kim,Ekaterini Tsilou,Zhengping Zhuang,Russell R. Lonser +6 more
TL;DR: Optimum treatment is multidisciplinary because of the complexities associated with management of the multiple, progressive, and protean lesions associated with the disorder.
Journal ArticleDOI
Germline Mutations of the MEN1 Gene in Familial Multiple Endocrine Neoplasia Type 1 and Related States
Sunita K. Agarwal,Mary Beth Kester,Larisa V. Debelenko,Christina Heppner,Michael R. Emmert-Buck,Monica C. Skarulis,John L. Doppman,Young Sik Kim,Irina A. Lubensky,Zhengping Zhuang,Jane Green,Sirandanahalli C. Guru,Pachiappan Manickam,Shodimu Emmanuel Olufemi,Lance A. Liotta,Settara C. Chandrasekharappa,Francis S. Collins,Allen M. Spiegel,A. Lee Burns,Stephen J. Marx +19 more
TL;DR: Familial multiple endocrine neoplasia type 1 (FMEN1) is an autosomal dominant trait characterized by tumors of the parathyroids, gastro-intestinal endocrine tissue, anterior pituitary and other tissues, supporting the prediction that MEN1 is a tumor suppressing gene.