Zhonggui He

TL;DR: The endocytic pathways are introduced, new technologies to confirm the specific endocytical pathways are presented and factors for pathway selection are discussed, which may provide new thoughts for the design of novel multifunctional nanomedicines.

TL;DR: This novel prodrug-nanosystem addresses concerns related to the low drug loading and inefficient drug release from hydrophobic prodrugs of PTX, and provides possibilities for the development of redox dual-sensitive conjugates or polymers for efficient anticancer drug delivery.

TL;DR: Prodrug-based nanocarriers for cancer therapy are discussed, including nanosystems based on polymer-drug conjugates, self-assembling small molecular weight prodrugs and prodrug-encapsulated nanoparticles (NPs).

TL;DR: The redox dual-responsive mechanism is elucidated, and how the position of disulfide bonds in the carbon chain affects the redoxDual responsiveness and antitumor efficiency of prodrug nanoassemblies is clarified.

TL;DR: This work presents proof-of-concept methodology and results in support of the hypothesis that disulfide-induced nanomedicines (DSINMs) are promoted and stabilized by the insertion of a single disulfides bond into hydrophobic molecules, in order to balance the competition between intermolecular forces involved in the self-assembly of nanomediines.