Z
Zhongjian Xie
Researcher at Central South University
Publications - 49
Citations - 2184
Zhongjian Xie is an academic researcher from Central South University. The author has contributed to research in topics: Keratinocyte & Involucrin. The author has an hindex of 23, co-authored 45 publications receiving 1830 citations. Previous affiliations of Zhongjian Xie include San Francisco VA Medical Center & University of California, San Francisco.
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Journal ArticleDOI
Calcium regulation of keratinocyte differentiation.
TL;DR: A number of signaling pathways involved with differentiation are regulated by calcium, including the formation of desmosomes, adherens junctions and tight junctions, which maintain cell–cell adhesion and play an important intracellular signaling role.
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Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.
TL;DR: A number of clinical conditions alter this relationship between total and free 25 hydroxyvitamin D levels, raising the question whether measuring just total 25(OH)D might be misleading regarding the assessment of vitamin D status, and such assessment might be improved by measuring free 25( OH)D instead of or in addition to total 20(OH), as well as different DBP alleles.
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Calcium- and vitamin D-regulated keratinocyte differentiation
TL;DR: The regulation of keratinocyte differentiation by calcium and 1,25(OH)(2)D involves a number of signaling pathways including PLC and PKC activation, leading to the induction of proteins required for the differentiation process.
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25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis
Daniel D. Bikle,Sandra Chang,Debra Crumrine,Hashem Z Elalieh,Mao-Qiang Man,Eung Ho Choi,Olivier Dardenne,Zhongjian Xie,R. St Arnaud,Kenneth R. Feingold,Peter M. Elias +10 more
TL;DR: The 25OHD 1OHase is essential for normal epidermal differentiation, most likely by producing the vitamin D metabolite, 1,25(OH)(2)D, responsible for inducing the proteins regulating calcium levels in the epidermis that are critical for the generation and maintenance of the barrier.
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Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes.
TL;DR: The results indicate that the CaR regulates cell survival and Ca2+o-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling.