Showing papers in "Journal of Investigative Dermatology in 2004"

TL;DR: The results strongly suggest that the two kalikreins are involved in desquamation, a model that could be regulated by a precisely controlled protease-protease inhibitor balance.

TL;DR: Findings suggest the existence of possible cooperation between BRAF activation and PTEN loss in melanoma development, and hypothesized that BRAF andPTEN/MMAC1 mutations may cooperate to promote melanoma tumorigenesis.

TL;DR: S100 proteins are of interest as mediators of calcium-associated signal transduction and undergo changes in subcellular distribution in response to extracellular stimuli and may play a role in the pathogenesis of epidermal disease, as selected S100 protein genes are markedly overexpressed in psoriasis, wound healing, skin cancer, inflammation, cellular stress, and other epidersmal states.

TL;DR: The present investigation clearly contradicts former hypothesis that the amount of appendages of the total skin surface represents not more than 0.1% and leads to a differential evaluation of skin penetration processes and a completely different understanding of penetration of topically applied drugs and cosmetics.

TL;DR: It is proposed that neural network analysis of near-infrared Fourier transform Raman spectra could provide a novel method for rapid, automated skin cancer diagnosis on unstained skin samples.

TL;DR: The basis for follicular targeting of essential structures containing stem cells for keratinocytes, melanocytes, and mast cells has been laid and a selective penetration route of the microspheres into the HF is demonstrated.

TL;DR: The reproductive hormones FSH, LH were unchanged but minor differences in testosterone levels were observed between the 2 wk and a minor difference in serum estradiol and inhibin B levels was observed in men only, which were not related to sunscreen exposure.

TL;DR: Dose-dependent associations with both the rate and extent of clinical response were observed across the four dose groups, and significant and sustained concentration-dependent improvements in psoriatic lesions were observed in most subjects.

TL;DR: Reduction in SMase-generating ceramides and impaired differentiation are involved in the defective barrier function found in AD.

TL;DR: Combining the previously described structural and Doppler imaging functions with polarization-sensitive imaging increases the utility of the technique for rapid, non-invasive investigations in the skin.

TL;DR: GTP as a dietary supplement could be useful to attenuate solar UVB light-induced premature skin aging, and treatment resulted in inhibition of UVB-induced protein oxidation in vivo in mouse skin, a hallmark of photoaging.

TL;DR: Values from aqueous solution across human skin were acquired or estimated from experimental data and correlated with solute physicochemical properties and it was found that the dermal resistance term was unnecessary for in vivo predictions for most solutes.

TL;DR: Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes.

TL;DR: RA is a potent inhibitor of beta-defensin induction in keratinocytes and might downregulate the inducible innate chemical defense system of human skin.

TL;DR: Results indicate that cytokine dysregulation associated with prolonged TNF expression represents a mechanism through which bacteria may induce a more damaging inflammatory response in diabetic individuals.

TL;DR: In this article, mutations in the BRAF, N-ras, and CDKN2A genes were found in 27 melanocytic nevi and corresponding surrounding tissues from 17 individuals.

TL;DR: The dissimilarity between clinical severity assessment and patient-centered measures stresses the need for a more comprehensive assessment of severity of psoriasis.

TL;DR: It is demonstrated that treatment of cultured human keratinocytes with ciglitazone, a PPAR-gamma activator, increases involucrin and transglutaminase 1 mRNA levels, and topical treatment of hairless mice with cig litazone or troglitaz one increases loricrin, involucarin, and filaggrin expression without altering epidermal morphology, which indicates that PPARS activation stimulates keratinocyte differentiation.

TL;DR: It is shown that GLI2 binds the GLI-binding consensus sequence in theGLI1 promoter, and in situ hybridization, this data suggest thatGLI2 directly activates GLI1 and that retrovirally expressed GLI 2 induces expression of endogenous GLI 1 in human primary keratinocytes.

TL;DR: It is hypothesized that fibroblasts in severely damaged skin have less interaction with intact collagen and as a result experience a reduction in mechanical tension, and decreased collagen synthesis is (presumed to be) the result.

TL;DR: The findings suggest that SCCE could have an important role in the development of atopic dermatitis, and a significant trend between the AACC allele with the two insertions and disease in the overall data set is found.

TL;DR: Insights into the negative impact of stress on hair growth and the integration of stress-coping strategies into the management of hair loss disorders as well as the development of new pharmacotherapeutic strategies might lead to enhanced therapeutic modalities with the alleviation of clinical symptoms.

TL;DR: Tea tree oil and terpinen-4-ol are able to impair the growth of human M14 melanoma cells and appear to be more effective on their resistant variants, which express high levels of P-glycoprotein in the plasma membrane, overcoming resistance to caspase-dependent apoptosis exerted by P- Glycoprotein-positive tumor cells.

TL;DR: In this article, the mtDNA mutations were induced in the human skin by repetitive UV exposure, leading to an approximately 40% increase in the levels of the common deletion in normal human skin.

TL;DR: Results indicate that mechanical stretching induces proliferative signals on human keratinocytes via induction of calcium influx, phosphorylation of epidermal growth factor receptor (EGFR), and ERK1/2, which may contribute to the hyperproliferative nature of the epidermis, which is mechanically stretched by various stimuli.

TL;DR: The hypothesis that the production of Fas-L, TNF-alpha, and IL-10 by keratinocytes could be a defense mechanism against CTL rather than a way of propagating apoptosis among epidermal cells is proposed.

TL;DR: Examination of EGFR null- and wild-type skin after injury demonstrates that EGFR regulates multiple facets of cutaneous wound healing, including inflammation, wound contraction, proliferation, migration, and angiogenesis.

TL;DR: Incidence of BCC in the Netherlands is increasing rapidly, especially at body sites that are not chronically exposed to sunlight, and the most likely explanation is an increased intermittent overexposure to UV radiation.