Z
Zichao Luo
Researcher at National University of Singapore
Publications - 47
Citations - 1776
Zichao Luo is an academic researcher from National University of Singapore. The author has contributed to research in topics: Adjuvant & Immune system. The author has an hindex of 17, co-authored 39 publications receiving 1198 citations. Previous affiliations of Zichao Luo include Chinese Academy of Sciences & Wenzhou Medical College.
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Journal ArticleDOI
A Powerful CD8+ T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant.
Zichao Luo,Qinjie Wu,Chengbiao Yang,Huaimin Wang,Tao He,Youzhi Wang,Zhongyan Wang,Hao Chen,Xingyi Li,Changyang Gong,Zhimou Yang +10 more
TL;DR: A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported, expected to enable a wide range of sub-unit vaccines and help the production of antibodies.
Journal ArticleDOI
Enzyme-Catalyzed Formation of Supramolecular Hydrogels as Promising Vaccine Adjuvants
Huaimin Wang,Zichao Luo,Youzhi Wang,Tao He,Chengbiao Yang,Chunhua Ren,Linsha Ma,Changyang Gong,Xingyi Li,Zhimou Yang +9 more
TL;DR: The d‐peptide hydrogel with OVA exhibits a slightly more efficient accumulation of OVA in the lymph nodes and seems preventing tumor growth more significantly than its l‐counterpart, suggesting big potential for the production of protein vaccines for immunotherapy against different diseases.
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Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses.
Ping Li,Zichao Luo,Peng Liu,Ningning Gao,Yijuan Zhang,Hong Pan,Lanlan Liu,Ce Wang,Lintao Cai,Yifan Ma +9 more
TL;DR: The in vitro study showed that reducible AP-SS nanogels not only facilitated antigen uptake by mouse bone marrow dendritic cells (BMDCs), but also promoted intracellular antigen degradation and cytosolic release.
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Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo.
TL;DR: In vivo co-delivery of immunopotentiator (PIC) and immunosuppressive gene silencer (STAT3 siRNA) by nanovaccines are expected to be a promising strategy to improve the therapeutic efficacy of cancer vaccines by modulating TADCs and overcoming tumor immunosupression.
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In situ covalently cross-linked PEG hydrogel for ocular drug delivery applications.
Jing Yu,Xu Xu,FuLin Yao,Zichao Luo,Ling Jin,Binbin Xie,Shuai Shi,Huixiang Ma,Xingyi Li,Hao Chen +9 more
TL;DR: It could be concluded that the developed PEG hydrogels as an injectable hydrogel might be suitable for extended Avastin(®) release to treat the corneal neovascularization.