Z
Zimo Yang
Researcher at Tsinghua University
Publications - 9
Citations - 189
Zimo Yang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 4, co-authored 5 publications receiving 94 citations.
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Journal ArticleDOI
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders.
Shang Su,Zimo Yang,Hongying Gao,Haiyan Yang,Songbiao Zhu,Zixuan An,Juanjuan Wang,Qing X. Li,Sarat Chandarlapaty,Haiteng Deng,Wei Wu,Yu Rao +11 more
TL;DR: A focused PROTAC library hijacking cancer therapeutic target CDK6 was developed and strongly inhibited proliferation of haematopoietic cancer cells including multiple myeloma and robustly degraded copy-amplified/mutated forms ofCDK6, indicating future potential clinical applications.
Journal ArticleDOI
Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.
TL;DR: It is revealed that synthetic lanosterol analogues could reverse multiple types of mutant-crystallin aggregates in cell models with excellent potency and efficacy and can improve the viability of the HLE-B3 cell line.
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One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(II)-catalyzed cascade C(sp3)–H activations
TL;DR: These quaternary carbon centered cyclobutanes could be further diversified through Pd(ii)-catalyzed γ-C(sp3)-H bond activations and the synthetic utility was exemplified by its application to the synthesis of a bioactive small molecule.
Journal ArticleDOI
Discovery of an insulin‐induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element‐binding protein–mediated lipogenesis
Shi Dong Jiang,Xinglin Yang,Zimo Yang,Jue-Wan Li,Meng-Qiang Xu,Yuxiu Qu,Jing-Jie Tang,Yun-Feng Li,Liguo Wang,Yiwen Shao,Xinyuan Meng,Huili Hu,Bao-Liang Song,Yu Rao,Wei Qi +14 more
TL;DR: This work aims to discover small molecules for treating NASH by inhibiting the SREBP pathway, which is found to be abnormally activated in NASH patients.
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Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
TL;DR: Compound 2, the newly synthesized N-oxide metabolite in N,N,N'-trimethylethylenediamine side chain of osimertinib showed a comparable kinase selectivity in vitro and a slightly better antitumor efficacy in vivo to osimerinib, making it valuable and suitable for the potential lung cancer therapy.