Ziyang Cao

TL;DR: A thieno-isoindigo derivative-based semiconducting polymer, PBTPBF-BT, formulated into PEGylated nanoparticles exhibited strong absorption in NIR-II region, inherent high photothermal conversion efficacy, and excellent photostability, suggesting the great probability of using NPPBTP BF-BT for in vivo PA imaging-guided PTT in the Nir-II window.

TL;DR: A reactive oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NPCe6/DOX was explored to realize remotely controlled drug release by light-activated size shrinkage by triggering rapid DOX release.

TL;DR: The use of cascade chemo-photodynamic therapy with reactive oxygen species (ROS)-sensitive lipid-polymer hybrid nanoparticles TKHNP-C/D to potentiate the antitumor efficacy of anti-PD-L1 antibody to generate an abscopal effect which could simultaneously inhibit primary and distant tumor growth.

TL;DR: It is demonstrated that the high PEGylation of TK-NPCe6&PTX in blood helps the nanocarrier efficiently avoid rapid clearance and consequently prolongs its circulation time, and this strategy of photoinducing PEG deshielding ofnanocarriers could potentially extend to a variety of therapeutic agents beyond anticancer drugs for on-demand delivery.

TL;DR: An innovative hyperbranched polyphosphate (RHPPE) containing a singlet oxygen (SO)-labile crosslinker to boost drug release during the photodynamic therapy (PDT) process is explored, providing an alternative avenue to achieve a cascade of amplified synergistic effects of chemo-photodynamic therapy for cancer treatment.