Z
Zofia M.A. Chrzanowska-Lightowlers
Researcher at Newcastle University
Publications - 114
Citations - 5426
Zofia M.A. Chrzanowska-Lightowlers is an academic researcher from Newcastle University. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 42, co-authored 112 publications receiving 4817 citations. Previous affiliations of Zofia M.A. Chrzanowska-Lightowlers include Baylor College of Medicine & Wellcome Trust.
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Journal ArticleDOI
Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis.
Fiona M. Menzies,Mark R. Cookson,Robert W. Taylor,Douglass M. Turnbull,Zofia M.A. Chrzanowska-Lightowlers,Lichun Dong,Denise A. Figlewicz,Pamela J. Shaw +7 more
TL;DR: It is concluded that one important mechanism by which mutant SOD1 causes motor neurone injury involves inhibition of specific components of the mitochondrial electron transfer chain.
Journal ArticleDOI
Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence
Haoran Tai,Zhe Wang,Hui Gong,Xiaojuan Han,Jiao Zhou,Xiaobo Wang,Xiawei Wei,Yi Ding,Ning Huang,Jianqiong Qin,Jie Zhang,Shuang Wang,Fei Gao,Zofia M.A. Chrzanowska-Lightowlers,Rong Xiang,Hengyi Xiao +15 more
TL;DR: It is found that mitochondrial dysfunction plays an initiating role, while lysosomal dysfunction is more directly responsible for autophagy impairment and senescence, and the effect of rapamycin on autophagic flux is linked to its role in functional revitalization of both mitochondrial and lysOSomal functions.
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GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules
Alexis A. Jourdain,Mirko Koppen,Mateusz Wydro,Chris D. Rodley,Robert N. Lightowlers,Zofia M.A. Chrzanowska-Lightowlers,Jean-Claude Martinou +6 more
TL;DR: These findings suggest that the foci containing GRSF1 and RNase P correspond to sites where primary RNA transcripts converge to be processed, and are termed “mitochondrial RNA granules.”
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Human mitochondrial mRNAs--like members of all families, similar but different.
TL;DR: The extent to which human mitochondrial mRNA species differ from one another is examined, finding only two molecules fit this pattern.
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A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome
Ricarda Richter,Joanna Rorbach,Aleksandra Pajak,Paul M. Smith,Hans J. C. T. Wessels,Martijn A. Huynen,Jan A.M. Smeitink,Robert N. Lightowlers,Zofia M.A. Chrzanowska-Lightowlers +8 more
TL;DR: It is reported that ICT1 is an essential mitochondrial protein, but unlike the other family members that are matrix‐soluble, ICT 1 has become an integral component of the human mitoribosome.