Zofia Ostrowska

TL;DR: Cofilins are evolutionary conserved proteins present in all Eukaryotic cells, involved in development of cancer, neurodegenerative diseases, congenital myopathies and cardiomyopathies, and cofilin 2, which dominates in mature skeletal and cardiac muscles.

TL;DR: The results reveal that isoform‐specific interactions with actin filament permit tropomyosins to discriminate between cofilin isoforms and to differentially regulate their activities.

TL;DR: The results suggest that CacyBP/SIP, through its interaction with both actin and tropomyosin, regulates the organization and functional properties of the thin filament.

TL;DR: The effects of actin dynamics regulation by four cytoskeletal tropomyosin isoforms and cofilin-1 were studied with the use of biochemical and fluorescent microscopy assays and it was concluded that the effects were executed through different actin affinities of tropomyOSinisoforms and cooperativities of tropomeosin and coFilin- 1 binding.

TL;DR: It is demonstrated that the myopathy-causing mutations affected tropomyosin structure and led to changes in interactions between tropomyo-troponin and troponin, which impaired the transition of the thin filament from the inactive off to the active on state.