Margaret T. Willard

TL;DR: These data establish 2ME2 as a small molecule inhibitor of HIF-1 and provide a mechanistic link between the disruption of the MT cytoskeleton and inhibition of angiogenesis.

TL;DR: It is shown that treatment of prostate cancer PC-3 and LNCaP cells with the benzoquinone ansamycin geldanamycin, an Hsp90-specific inhibitor, induced degradation of HIF-1alpha protein in a dose- and time-dependent manner under both normoxia and hypoxia.

TL;DR: This study demonstrates that the CXCR4/CXCL12 signaling axis can induce angiogenesis and progression of tumors by increasing expression of VEGF through the activation of PI3K/Akt pathway.

TL;DR: Diverse neoplastic lesions, including colon cancer and melanoma-derived cells lines, expressed both Tn and STn antigen due to loss-of-function mutations in Cosmc, the first example of somatic mutations in multiple types of cancers that cause global alterations in cell surface carbohydrate antigen expression.

TL;DR: Androgens activate HIF-1, driving VEGF expression in androgen-sensitive LNCaP cells, and this regulation is mediated through an autocrine loop involving EGF/phosphatidylinositol 3'-kinase/protein kinase B, which in turn activate Hif-1alpha and H IF-1-regulated gene expression.