Z
Zoya Volovyk
Researcher at University of North Carolina at Chapel Hill
Publications - 6
Citations - 1806
Zoya Volovyk is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Thrombin & Lipid raft. The author has an hindex of 5, co-authored 6 publications receiving 1750 citations.
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Journal ArticleDOI
Lipid rafts reconstituted in model membranes.
Christian Dietrich,Luis A. Bagatolli,Zoya Volovyk,Nancy L. Thompson,Moshe Levi,Ken Jacobson,Enrico Gratton +6 more
TL;DR: The notion that in biomembranes selected lipids could laterally aggregate to form more ordered, detergent-resistant lipid rafts into which glycosphingolipid- and cholesterol-rich lipid domains partition is strongly supported by this study.
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Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers.
TL;DR: It is shown that cross-linking, a process known to be important for certain cell-signaling processes, can selectively translocate molecules to liquid-ordered domains, and that domain formation and disruption critically depends on the cholesterol density.
Journal ArticleDOI
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
Shahid M Nimjee,Sabah Oney,Zoya Volovyk,Kristin M. Bompiani,Steve B. Long,Maureane Hoffman,Bruce A. Sullenger +6 more
TL;DR: It is observed that simultaneously blocking both exosites with the aptamers leads to synergistic inhibition of thrombin-dependent platelet activation and procoagulant activity, suggesting a combination of exosite 1 and exosite 2 inhibitors may provide a particularly effective antithrombotic approach.
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Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.
TL;DR: A cell-based model reflects the effects on thrombin generation of clinically relevant levels of FVIIa and PCC in the presence of dabigatran and appears to correlate best with hemostasis in vivo.
Journal Article
Lipid rafts in model and biological membranes
Ken Jacobson,Zoya Volovyk,Nancy L. Thompson,Luis A. Bagatolli,Enrico Gratton,Moshe Levi,Christian Dietrich +6 more
TL;DR: Using fluorescence microscopy, less fluid domains with raft-like properties were found to coexist with more fluid lipid regions in both planar supported lipid layers and in giant unilamellar vesicles formed from equimolar mixtures of phospholipid-cholesterol- sphingomyelin.