M
Maureane Hoffman
Researcher at Duke University
Publications - 209
Citations - 14249
Maureane Hoffman is an academic researcher from Duke University. The author has contributed to research in topics: Coagulation & Tissue factor. The author has an hindex of 58, co-authored 203 publications receiving 13157 citations. Previous affiliations of Maureane Hoffman include United States Department of Veterans Affairs & North Carolina State University.
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Journal ArticleDOI
A cell-based model of hemostasis
TL;DR: This model emphasizes the importance of specific cellular receptors for the coagulation proteins and explains some aspects of hemostasis that a protein-centric model does not.
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Platelets and Thrombin Generation
TL;DR: Examination of evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation concludes that changes in lipid composition are necessary but not sufficient to account for platelet surface regulation of thROMbin generation.
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Platelet activity of high‐dose factor VIIa is independent of tissue factor
TL;DR: It is reported that factor VIIa bound weakly to activated platelets and could initiate thrombin generation in the presence of plasma concentrations of prothrombin, factor X, factor V, antithrombin III and tissue factor pathway inhibitor.
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Platelet functions beyond hemostasis
Susan S. Smyth,Rodger P. McEver,Andrew S. Weyrich,C. N. Morrell,Maureane Hoffman,Gowthami M. Arepally,Patricia A. French,Harold L. Dauerman,Richard C. Becker +8 more
TL;DR: The process of and factors mediating platelet–platelet and platelet-leukocyte interactions in inflammatory and immune responses are discussed, with the roles of P‐selectin, chemokines and Src family kinases being highlighted.
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The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients
TL;DR: FVIIa should be effective in enhancing hemostasis in hypothermic patients, however, because the activity of FVIIa is so dramatically affected by pH, its efficacy may be reduced in acidotic patients.