Showing papers by "Cancer Research Institute published in 1972"
TL;DR: Glass adhesiveness, phagocytic ability, and surface receptors for immunoglobulins appeared to increase with cell maturation from the promonocyte through the macrophage stage of development, and with progressive cellular maturation, peroxidase activity disappeared after the monocyte stage.
56 citations
TL;DR: Treatment of the concanavalin A with Mn2+ and Ca2+ rendered the protein homogeneous with respect to carbohydrate-binding ability.
32 citations
01 Jan 1972
TL;DR: Experimental data and some clinical observations show that radioactive iodine (131I) is able to cause thyroid tumours both in animals and in man.
Abstract: Thyroid carcinomas have recently become one of the main problems in theoretical, experimental and clinical oncology. This is due, on the one hand, to their specific biological properties with regard to growth, metastasis, functional activity, hormonal control, radiobiological changes after treatment with 131I and resistance to antitumour agents, and, on the other hand, to the possibility of studying them by means of radioactive iodine. There is no other type of tumour in the human body presenting a more favourable target for functional investigations than thyroid tumours. The wide use of radioactive iodine in the diagnosis and treatment of thyroid diseases inevitably brought up the problem of its carcinogenic effect. Experimental data and some clinical observations show that radioactive iodine (131I) is able to cause thyroid tumours both in animals and in man. The increased incidence of thyroid cancer among patients irradiated in childhood for thymic enlargement is indicative of the significant participation of X-ray irradiation in thyroid carcinogenesis.
27 citations
TL;DR: The mammographic and pathologic material of 58 women who underwent radical mastectomy for infiltrating duct carcinoma was reviewed, and a statistically significant increase in the frequency of axillary lymph node metastasis accompanied carcinomas which in mammograms appeared highly rather than slightly infiltrative.
Abstract: The mammographic and pathologic material of 58 women who underwent radical mastectomy for infiltrating duct carcinoma was reviewed. A statistically significant increase in the frequency of axillary lymph node metastasis accompanied carcinomas which in mammograms appeared highly rather than slightly infiltrative. Among the 52 cases in which approximate tumor volume could be determined, a significantly greater proportion of highly infiltrative tumors was found among small tumors than among large tumors. Highly infiltrative tumors of large size metastasized to axillary lymph nodes more often than did those of small size. These results imply that the extent of macroscopic local tumor infiltration as recorded by mammography can serve as a guide to the frequency of concomitant metastasis to the axillary lymph nodes.
11 citations
3 citations