Showing papers by "CHU Ambroise Paré published in 2009"

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.

Abstract: Background We investigated the efficacy of cetuximab plus irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment for metastatic colorectal cancer and sought associations between the mutation status of the KRAS gene in tumors and clinical response to cetuximab. Methods We randomly assigned patients with epidermal growth factor receptor–positive colorectal cancer with unresectable metastases to receive FOLFIRI either alone or in combination with cetuximab. The primary end point was progression-free survival. Results A total of 599 patients received cetuximab plus FOLFIRI, and 599 received FOLFIRI alone. The hazard ratio for progression-free survival in the cetuximab–FOLFIRI group as compared with the FOLFIRI group was 0.85 (95% confidence interval [CI], 0.72 to 0.99; P=0.048). There was no significant difference in the overall survival between the two treatment groups (hazard ratio, 0.93; 95% CI, 0.81 to 1.07; P=0.31). There was a significant interaction between treatment group and KRAS ...

Assessment of spinal somatosensory systems with diffusion tensor imaging in syringomyelia

Abstract: OBJECTIVE: We tested the use of diffusion tensor imaging with three-dimensional fiber tracking (DTI-FT) for the assessment of spinal sensory tract lesions. We systematically examined the relationships between tract lesions quantified with DTI-FT, and somatosensory dysfunction assessed with quantitative sensory testing (QST) and laser evoked potentials (LEP), in patients with syringomyelia. METHODS: We studied 28 patients with cervical syringomyelia and thermosensory impairment of the hands, and 19 healthy volunteers. We performed a DTI-FT of the spinal cord focusing on the upper segment (C3-C4) of the syrinx. Three-dimensional DTI-FT parameters (i.e. fractional anisotropy (FA) and apparent diffusion coefficient (ADC)) of the full, anterior and posterior spinal cord were individually compared to QST (i.e. thermal detection thresholds) and LEP (i.e. amplitude, latency and spinothalamic tract (STT) conduction time) of the hands. RESULTS: Patients had a significantly lower FA, but not ADC, than healthy subjects. Mean FA of the full section of the spinal cord was related both to sensory deficits (i.e. increase of warm (rho = -0.63, p<0.010) and cold thresholds (rho = -0.72;p< 0.001 of the hands) and to changes in LEP parameters, in particular STT conduction time (rho = -0.75;p<0.010). Correlations between FA and the clinical and electrophysiological measurements were higher in the anterior area (where the STT is confined) than in the posterior area of the spinal cord. CONCLUSIONS: These data indicate that diffusion tensor imaging with 3D-fiber tracking is a new imaging method which is suitable for the objective and quantitative anatomical assessment of spinal somatosensory system dysfunction.

Dotlike or Golgi-like KIT and PDGFRA Staining in GISTs.

Abstract: 277–283. 3. McNiff J, McCalmont TH, Requena L, et al. Tubular and tubular papillary adenoma. In: Leboit PE, Burg G, Weedon G, et al, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. Lyon: IARC Press; 2006:145–146. 4. Obaidat NA, Awamleh AA, Ghazarian DM. Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region. Eur J Dermatol. 2006; 16:576–578. 5. Robson A, Lazar AJ, Ben Nagi J, et al. Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases. Am J Surg Pathol. 2008;32:682–690. 6. Weinreb I, Tabanda-Lichauco R, Van der Kwast T, et al. Low-grade intraductal carcinoma of salivary gland: report of 3 cases with marked apocrine differentiation. Am J Surg Pathol. 2006;30:1014–1021. 7. Wick MR, Ockner DM, Mills SE, et al. Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma. Am J Clin Pathol. 1998;109:75–84. 8. Yoshida A, Kodama Y, Hatanaka S, et al. Apocrine adenocarcinoma of the bilateral axillae. Acta Pathol Jpn. 1991;41:927–932.

Irinotecan as palliative chemotherapy for metastatic colorectal cancer: evolving tactics following initial treatment.

Abstract: Background Patients with metastatic colorectal cancer (mCRC) who progress despite treatment with fluoropyrimidine and irinotecan or oxaliplatin have diminished survival, but they may derive clinically meaningful benefit from second-line or later chemotherapy.

Emotions: Theoretical Models and Clinical Implications

Abstract: The confrontation between theory and clinical practice contributes to improve our knowledge of emotions. In the present paper, theoretical models both cognitive and biological are briefly reviewed in the first part. Interactions between research and clinical practice are examined across two separate approaches in the second part. The first, neuropsychological approach considers Alzheimer’s disease to further explore relationships between emotions and memory disturbance. The second considers panic disorder to explore cognitive and behaviour theories of fear. Finally, we address therapeutic applications for each approach which come directly from the theory.

Maladie de BoWen

Abstract: La maladie de Bowen est un carcinome epidermoide cutane ou muqueux intraepithelial Elle a ete decrite par John Bowen (1857–1941) en 1912 Son evolution vers un cancer invasif avec atteinte du chorion est lente, ne survenant qu’apres plusieurs mois ou annees