Showing papers by "Dr. Hari Singh Gour University published in 1990"

Effervescent granule based proliposomes of ibuprofen

Abstract: Proliposomes of ibuprofen were successfully prepared using effervescent granules as solid carriers of dried phospholipids along with other lipids (soyabean lecithin, stearylamine and cholesterol). Liposomes of regular size with uniform size distribution resulted when proliposomal formulations were hydrated under the effervescence produced by the production of carbon dioxide gas. The inert atmosphere of carbon dioxide gas prevents the chance of oxidative degradation of phospholipids. The size distribution of liposomes was noted to be related to the degree of agitation provided by effervescence. Encapsulation efficiency of liposomes derived from proliposomes was shown to be nearly 100 per cent. Preparations were shown to be quite stable at 20 degrees C when stored under an umbrella of nitrogen. The enhanced anti-inflammatory activity of ibuprofen entrapped in liposomes was exhibited when compared with plain ibuprofen following intravenous administration using the carrageenan induced paw oedema test.

Effect of Vegetable Oils on the Ovipositional Behaviour of Callosobruchus Maculatus (Fabricius)

Abstract: Effects of nine vegetable oils viz., Pongamia glabra, Madhuca indica, Ricinus communis, Brassica sp., Azadirachta indica, Cymbopogon citratus, Cocos nucifera, Cymbopogon nardus, and Arachis hypogea at three different concentrations (0.2, 0.4, and 0.8% w/w) were studied on the oppositional behaviours of Callosobruchus maculatus (Fabricius) at 27 ± 1°C and 70% R.H. Oviposition was completely inhibited by the seed treatment of Pongamia oil in each dose just after the treatment but its efficacy sharply deteriorated at later stages of sampling (30, 60 and 90 days after treatment). Cymbopogon nardus and C. citratus oils were effective even up to 90 days of treatment. Dose to dose variations were significant at each stage of sampling.

Preparation, characterization and performance evaluation of neomycin-HSA microspheres.

Abstract: Human serum albumin microspheres containing neomycin sulphate were prepared using emulsion polymerization and polymer dispersion techniques. The many variables which may affect the shape, size, stability, release of the drug from the microspheres such as internal phase to external phase volume ratio, human serum albumin content, stirring rate, polymer content and stabilizing agent concentration, were studied. Unlike the microspheres prepared by the emulsion polymerization technique, polymer dispersion stabilised microspheres were uniform in size and shape with a narrow range of size distribution. In vitro release of neomycin sulphate from albumin microspheres was studied using the dialysis cell method. The drug release from microspheres followed Q versus (t)-1/2 linear relationship. The in vivo distribution studies on prepared microspheres revealed that the localization takes place preferably in lung tissues, liver, spleen and kidney and is found to be dependent on the microsphere size. On administration of microspheres of 3-6 microns size, approximately 55 per cent of administered drug could be localized in the lungs.

Salbutamol Delivering Transdermal Dosage Form Based on Osmo-Regulatory Principle

Abstract: A transdermal drug delivery system of Salbutamol was developed which released the drug following zero order kinetics. The designed system essentially based on trilaminated matrix concept. The delivery of drug from the system affected by osmotic phenomenon where sodium chloride was used as an osmogent. To establish the desired release rate polyethylene glycol 4000 (PEG 4000) was used as channelising agent in rate controlling membrance of cellulose acetate. The designed systems exhibiting zero-order release rate, were studied for the in-vitro skin permeation. The product which was having skin permeability rate 115 mcg/hr/cm2 was selected for the in-vivo evaluation. The forced expiratory volume (FEV1) and drug plasma concentration were monitored periodically. The study revealed that designed osmoregulatory transdermal drug delivery system of Salbutamol could be used successfully with improved therapeutic response and holds promise for the clinical studies.

Synthesis and Reactivity of Some N,N-Bis(3-nitrobenzylidene)ethylenediamine Diphenyltin Salts

Abstract: A series of seven new complexes of organotin(IV) of the general formula [Ph2SnL]X2 where L = N,N-bis(3-nitrobenzylidene) ethylenediamine and X = Cl−, ClO4 −, NO3 −, BF4 − have been prepared and their reactivity, using a variety of reagents and resulting in ten new derivatives, has been studied. The Sn-C bond remains stable and intact in many interesting interconversions of these derivatives and the functional groups on the 3-position of benzene ring were found to be intramolecularly coordinated to the tin atom giving octahedral geometry to the new complexes.

Development and Performance Evaluation of Controlled Release Osmo-Sinosules of Chlorpromazine Hydrochloride.

Abstract: The controlled release osmo-regulatory sinosules of chlorpromazine hydrochloride (Cpz.OR.CR) were prepared. Cpz.HCl granules containing, powdered sucrose (an osmogent) and soluble lactose were coated employing 12.5% w/v polybutylmethacrylate (PBMA): polyvinylacetate (PVA) (80:20) solution containing varied quantity of channeling agent and plasticizer. At 10:1 core to coat ratio the prepared sinosules released the drug @6.50 mg/h following zero-order kinetics when tested for in vivo performance in Indian dogs and compared with conventional tablet Largactil® 25. The Cpz.OR.CR maintained uniform blood level around the peak level as compared with Largactil® 25 and resulted in significantly higher bioavailability of chlorpromazine.

Effect of whole pituitary extract on the corpuscles of stannius in Notopterus notopterus (Pallas).

Abstract: Administration of pituitary extract brings important change in the cells of the corpuscles of stannius. Two variety of cells are found in the corpuscles of stannius of control group, one with dense cytoplasm while the other possess non-reactive cytoplasm. Under the influence of whole pituitary extract, there is an intense cell activity in corpuscles of stannius suggesting more synthesis of hypocalcemic factor. Other possible reasons like stimulation of interrenal, thereby activating corpuscles of stannius have also been discussed. The possible involvement of ACTH or cortisol and synergistic effect of prolactin in promotion of hypercalcemia have also been suggested.