Facultad de Ciencias Médicas

About: Facultad de Ciencias Médicas is a based out in . It is known for research contribution in the topics: Population & Fatty acid. The organization has 4833 authors who have published 3708 publications receiving 38112 citations.

Hiperreactividad cardiovascular en pacientes con antecedentes familiares de hipertensión arterial

Abstract: Fundamento y objetivo La relacion entre historia familiar de hipertension arterial esencial y la hiperreactividad cardiovascular al ejercicio isometrico no es aun bien conocida. Por esa razon,el objetivo principal de este estudio es describir esa relacion y determinar si es independiente de la presencia de los factores de riesgos cardiovasculares. Pacientes y metodo Se realizo un estudio descriptivo correlacional con una muestra de 1.855 personas de ambos sexos, de entre 18 y 70 anos de edad. La hiperreactividad cardiovascular, expresion de la respuesta cardiovascular a la actividad del sistema nervioso simpatico, se con-siguio mediante la prueba del peso sostenido. Se desarrollaron comparaciones de los valores de reactividad cardiovascular entre los individuos con y sin historia familiar de HTA y un modelo de regresion logistica. El nivel de significacion estadistica fijado fue del 95%. Resultados La presion arterial media al final de la prueba del peso sostenido fue superior en los individuos con historia familiar de HTA independientemente del grupo de edad. La hiperre-actividad cardiovascular, medida mediante el indice de reactividad cardiovascular sistolica, tambien fue significativamente superior en los individuos con historia familiar de HTA. Porulti-mo, las personas que tienen una historia familiar de HTA presentan un riesgo de mas de 5 ve-ces de tener una hiperreactividad cardiovascular (odds ratio= 5,16, intervalo de confianza del 95%, 3,51-7,59), siendo esta asociacion independiente de otros factores de riesgo cardiovas-cular. Conclusiones La historia familiar de HTA esta relacionada con la hiperreactividad cardiovascu-lar al ejercicio isometrico independientemente de otros factores de riesgo cardiovascular. Este aspecto contribuye a explicar, al menos en un grupo elevado de personas, la relacion entre hi-peractividad del sistema nervioso simpatico y la HTA.

The effect of dehydroepiandrosterone sulfate and testosterone on the development of chick embryo frontal bones in vitro.

Abstract: Chick embryo frontal bones at 12 days of development, cultivated in vitro on plasma clots with dehydroepiandrosterone sulfate in a concentration 1mM, exhibit periosteal hyperplasia and increased synthesis of osteoid tissue. These phenomena are not observed when 11-day frontals are cultivated in similar conditions. Testosterone produces the same effects as dehydroepiandrosterone sulfate. Both steroids seem to act directly on bone as can be inferred from the experimental conditions employed. The alkaline phosphatase activity of chick embryo frontal bones at 12 days of development is significantly increased when the rudiments are cultivated in a medium containing dehydro-epiandrosterone or testosterone. In both cases a) enzyme kinetics experiments revealed that there is activation of the enzyme and b) the apparent maximum velocities obtained are hihgly correlated with the logarithm of the doses employed. When assayed simultaneously, both steroids were found equally active in promoting the increase in alkaliue phosphatase activity.

Ultrastructural and quantitative immunohistochemical changes induced by nonsteroid antiandrogens on pituitary gonadotroph population of prepubertal male rats

Abstract: Specific blockade of the androgen receptor by the nonsteroid antiandrogens flutamide and Casodex has proven to be a useful tool for studying androgens in vivo. The aim of the present study was to inve

Development of the secretory capacity of the chick embryo adrenal glands.

Abstract: The secretory capacity of the chick embryo adrenal was investigated at different stages of its development employing a sensitive bioassay for corticosteroids based upon the modifications produced in vitro by these hormones on the height of the chick embryo duodenal mucosa. The adrenal gland cultivated in contact with explants of duodenum and stimulated with increasing doses of ACTH exhibited a mucosal response similar to that produced by corticosterone, both in the slope of the bioassay dose—response curve and in the histological pattern. It has been found that the chick embryo adrenal glands can secrete corticoids from the 5th day onwards by adding ACTH to the culture medium. The basal (unstimulated) secretory capacity of the gland (registered from the 8th day on) is significantly correlated with the total protein content of the adrenals in the different stages of development studied. The maximal secretory capacity of the gland (measured with the dose of ACTH which produces the maximal response) increases steadily up to the 10th day. The rate of increase of corticosteroid secretion due to ACTH is a constant within the interval of development investigated.