Facultad de Ciencias Médicas

About: Facultad de Ciencias Médicas is a based out in . It is known for research contribution in the topics: Population & Fatty acid. The organization has 4833 authors who have published 3708 publications receiving 38112 citations.

Detection of circulating mammary mucin (MUC1) and MUC1 immune complexes (MUC1-CIC) in healthy women

Abstract: There is convincing epidemiological evidence that multiparity provides protection against the development of breast cancer. In the present study we evaluated the levels of MUC1 and MUC1 circulating...

Hypothermia prevents gliosis and angiogenesis development in an experimental model of ischemic proliferative retinopathy.

Abstract: Fil: Rey Funes, Manuel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Biologia Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biologia Celular y Neurociencia ; Argentina

The eggs of the apple snail Pomacea maculata are defended by indigestible polysaccharides and toxic proteins

Abstract: The freshwater snails Pomacea Perry, 1810 lay conspicuous aerial egg clutches that are ignored by most predators. Egg biochemical defenses in the apple snail Pomacea canaliculata (Lamarck, 1822) ar...

Reactive oxygen species in cancer: a paradox between pro- and anti-tumour activities

Abstract: Cancer constitutes a group of heterogeneous diseases that share common features They involve the existence of altered cellular pathways which result in uncontrolled cell proliferation Deregulation of production and/or elimination of reactive oxygen species (ROS) appear to be a relevant issue in most of them ROS have a dual role in cell metabolism: they are compromised in normal cellular homeostasis, but their overproduction has been reported to promote oxidative stress (OS), a process that may induce the damage of cell structures ROS accumulation is implicated in the activation of signaling pathways that promote cell proliferation and metabolic adaptations to tumour growth One characteristic of cancer cells is the sensitivity to OS, which often results from the combination of high anabolic needs and hypoxic growth conditions However, there is still no clear evidence about the levels of oxidant species that promote cellular transformation or, otherwise, if OS induction could be adequate as an antitumour therapeutic tool There is a need for novel therapeutic strategies based on the new knowledge of cancer biology Targeting oncogenic molecular mechanisms with non-classical agents and/or natural compounds would be beneficial as chemoprevention or new adjuvant therapies In addition, epigenetics and environment, and particularly dietary factors may influence the development and prevention of cancer This article will present a revision of the current research about molecular aspects proposed to be involved in the anticancer features of oxidant and antioxidant-based therapies targeting cancer cells, and their participation in the balance of oxidative species and cancer cell death