Facultad de Ciencias Médicas

About: Facultad de Ciencias Médicas is a based out in . It is known for research contribution in the topics: Population & Fatty acid. The organization has 4833 authors who have published 3708 publications receiving 38112 citations.

Calidad de la atención de salud: Error médico y seguridad del paciente

Abstract: Resumen es: El proposito de este trabajo es incentivar el interes por el diagnostico oportuno y la prevencion del error medico (EM), para lo cual se hizo una revisio...

Cuticular Hydrocarbon Variability Among Triatoma dimidiata (Hemiptera: Reduviidae) Populations from Mexico and Guatemala

Abstract: The geographic variation in the cuticular hydrocarbon pattern among 11 populations of Triatoma dimidiata Latreille (Hemiptera: Reduviidae: Triatominae) from different regions of Mexico and Guatemala, was studied using capillary gas chromatography. T. dimidiata populations were differentiated based on the relative amounts of 71 hydrocarbon components. Insect population classification was mostly in agreement with their geographical vicinity; Mexican populations from the Yucatan peninsula grouped together with those from northern Guatemala, insects from the Mexican Gulf coast states were closely related to those collected from northern Oaxaca, and to a lesser extent, to insects from Chiapas. Insects from southern Oaxaca were clustered together with those from southern Guatemala. All these populations were clearly separated from Guatemalan specimens collected in caves from Alta Verapaz.

Aminolevulinic acid dendrimers in photodynamic treatment of cancer and atheromatous disease.

Abstract: The use of endogenous protoporphyrin IX after administration of 5-aminolaevulinic acid (ALA) has led to many applications in photodynamic therapy (PDT). We have previously reported that the conjugation of ALA dendrimers enhances porphyrin synthesis. The first aim of this work was to evaluate the ability of ALA dendrimers carrying 6 and 9 ALA residues (6m-ALA and 9m-ALA) to photosensitise cancer cells. For this aim, we employed LM3 mammary carcinoma cells. In these tumour cells, at low concentrations porphyrin synthesis from dendrimers was higher compared to ALA, whereas at high concentrations, porphyrin synthesis was similar from both compounds. Topical application of ALA dendrimers on the skin overlying a subcutaneous LM3 implanted tumour showed no diffusion of the molecules either to distant skin sites or to the adjacent tumour, suggesting a promising use of the ALA macromolecules in superficial cancer models. As a second objective, we proposed the use of ALA-dendrimers in vascular PDT for the treatment of atherosclerosis. Thus, we focused our studies on ALA-dendrimer's selectivity towards macrophages in comparison with endothelial cells. For this aim we employed Raw 264.7 macrophages and HMEC-1 microvasculature cells. Porphyrin synthesis induced in macrophages by 6m-ALA and 9m-ALA (3 h, 0.025 mM) was 6 and 4.6 times higher respectively compared to the endothelial cell line, demonstrating the high affinity of ALA dendrimers for macrophages. On the other hand, ALA employed at low concentrations was slightly selective (1.7-fold) for macrophages. Inhibition studies suggested that ALA dendrimer uptake in macrophages is mainly mediated by caveloae-mediated endocytosis. Our main conclusion is that in addition to being promising molecules in PDT of superficial cancer, ALA dendrimers may also find applications in vascular PDT, since in vitro they showed selectivity to the macrophage component of the atheromatous plaque, as compared to the vascular endothelium.

The vascular anatomy of the rat's hypothalamus in stereotaxic coordinates

Abstract: The vascular antomy of the rat's hypothalamus was studied using the method of the India ink injections. A constant vascular pattern was found and a serial description of it is given, correlated with the nuclear and fibrilar anatomy in a system of stereotaxic coordinates. It was found that the vessels supplying certain areas follow a relatively long course and the hypothesis is advanced that their lesion could produce vascular disturbances in areas distant to that in which the electrode had been placed. Some previous results by other authors are discussed on these grounds.