Institution
Federal Almazov North-West Medical Research Centre
Facility•Saint Petersburg, Russia•
About: Federal Almazov North-West Medical Research Centre is a facility organization based out in Saint Petersburg, Russia. It is known for research contribution in the topics: Medicine & Pregnancy. The organization has 571 authors who have published 236 publications receiving 1119 citations. The organization is also known as: Almazov National Medical Research Centre & Polenov Research Institute of Neurosurgery.
Topics: Medicine, Pregnancy, Internal medicine, Vitamin D and neurology, Biology
Papers
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University of Paris-Sud1, Harvard University2, Actelion3, University College Dublin4, University of Bologna5, Imperial College London6, Hannover Medical School7, Medical University of Vienna8, University of California, San Diego9, Cedars-Sinai Medical Center10, Federal Almazov North-West Medical Research Centre11, Peking Union Medical College12, University of Michigan13
TL;DR: The risk of the primary composite end point of death or a complication related to pulmonary arterial hypertension was significantly lower with selexipag than with placebo and there was no significant difference in mortality between the two study groups.
Abstract: BackgroundIn a phase 2 trial, selexipag, an oral selective IP prostacyclin-receptor agonist, was shown to be beneficial in the treatment of pulmonary arterial hypertension. MethodsIn this event-driven, phase 3, randomized, double-blind, placebo-controlled trial, we randomly assigned 1156 patients with pulmonary arterial hypertension to receive placebo or selexipag in individualized doses (maximum dose, 1600 μg twice daily). Patients were eligible for enrollment if they were not receiving treatment for pulmonary arterial hypertension or if they were receiving a stable dose of an endothelin-receptor antagonist, a phosphodiesterase type 5 inhibitor, or both. The primary end point was a composite of death from any cause or a complication related to pulmonary arterial hypertension up to the end of the treatment period (defined for each patient as 7 days after the date of the last intake of selexipag or placebo). ResultsA primary end-point event occurred in 397 patients — 41.6% of those in the placebo group and...
713 citations
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25 Apr 2018
TL;DR: A third revision of the clinical recommendations for the treatment of morbid obesity in adults is presented in this article. But, the staging of prescribing conservative and surgical methods for treatment of obesity are determined.
Abstract: The presented paper is a third revision of the clinical recommendations for the treatment of morbid obesity in adults. Morbid obesity is a condition with body mass index (BMI) ≥40 kg / m2 or a BMI ≥35 kg / m2 in the presence of serious complications associated with obesity. The recommendations provide data on the prevalence of obesity, its etiology and pathogenesis, as well as on associated complications. The necessary methods for laboratory and instrumental diagnosis of obesity are described in detail. In this revision of the recommendations, the staging of prescribing conservative and surgical methods for the treatment of obesity are determined. For the first time, a group of patients with obesity and type 2 diabetes mellitus is selected, in whom metabolic surgery allows a long-term improvement in the control of glycemia or remission of diabetes mellitus.
72 citations
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TL;DR: Patients with a baseline BMI ≥30 kg/m2 have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
Abstract: Objectives The association between obesity and atrial fibrillation (AF) is well-established. We aimed to evaluate the impact of index body mass index (BMI) on AF recurrence at 12 months following catheter ablation using propensity-weighted analysis. In addition, periprocedural complications and fluoroscopy details were examined to assess overall safety in relationship to increasing BMI ranges. Methods Baseline, periprocedural and follow-up data were collected on consecutive patients scheduled for AF ablation. There were no specific exclusion criteria. Patients were categorised according to baseline BMI in order to assess the outcomes for each category. Results Among 3333 patients, 728 (21.8%) were classified as normal (BMI 2 ), 1537 (46.1%) as overweight (BMI 25.5–29.0 kg/m 2 ) and 1068 (32.0%) as obese (BMI ≥30.0 kg/m 2 ). Procedural duration and radiation dose were higher for overweight and obese patients compared with those with a normal BMI (p=0.002 and p 2 led to a 1.2-fold increased likelihood of experiencing recurrent AF at 12-months follow-up as compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011), while no significant correlation was found between overweight and normal BMI groups (HR 0.954; 95% CI 0.798 to 1.140; p=0.605) and obese versus normal BMI (HR 1.16; 95% CI 0.965 to 1.412; p=0.112). Conclusions Patients with a baseline BMI ≥30 kg/m 2 have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
62 citations
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TL;DR: The protocol of OCR assessment in the culture of primary myotubes obtained upon satellite cell fusion is described, which requires application of mitochondrial inhibitors to block ATP synthase and rotenone and antimycin A-to inhibit complexes I and III.
Abstract: Mitochondrial respiration is the most important generator of cellular energy under most circumstances. It is a process of energy conversion of substrates into ATP. The Seahorse equipment allows measuring oxygen consumption rate (OCR) in living cells and estimates key parameters of mitochondrial respiration in real-time mode. Through use of mitochondrial inhibitors, four key mitochondrial respiration parameters can be measured: basal, ATP production-linked, maximal, and proton leak-linked OCR. This approach requires application of mitochondrial inhibitors-oligomycin to block ATP synthase, FCCP-to make the inner mitochondrial membrane permeable for protons and allow maximum electron flux through the electron transport chain, and rotenone and antimycin A-to inhibit complexes I and III, respectively. This chapter describes the protocol of OCR assessment in the culture of primary myotubes obtained upon satellite cell fusion.
50 citations
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TL;DR: In this article, the analysis of the crystal structures of chitosan, its main polymorphic modifications, and its characteristic mutual chain packing and hydrogen bond systems in the crystalline regions of conformers is presented.
Abstract: This work describes the analysis of the crystal structures of chitosan, its main polymorphic modifications, and its characteristic mutual chain packing and hydrogen bond systems in the crystalline regions of conformers. The analysis takes into consideration the crystal structures of chitosan complexes (salts) with organic and inorganic acids and their structural transformations. Notably, the transformation of the hydrated form of chitosan into anhydrous is found to be irreversible and occurs either at high temperatures or through a less stable form of hydrated salts. The interaction with polyanions during the formation of multilayer films can be considered as a way to form the anhydrous crystalline form of chitosan.
47 citations
Authors
Showing all 602 results
Name | H-index | Papers | Citations |
---|---|---|---|
Evgeny Shlyakhto | 22 | 93 | 11042 |
Yury A. Skorik | 21 | 60 | 984 |
Aleksey V. Zaitsev | 21 | 101 | 1709 |
Anna Kostareva | 20 | 139 | 1500 |
Anna Malashicheva | 18 | 87 | 1208 |
Alexandra Konradi | 17 | 61 | 767 |
Sergey V. Kovalchuk | 15 | 119 | 817 |
Olga Moiseeva | 12 | 77 | 1361 |
Evgeny N. Mikhaylov | 11 | 51 | 469 |
Natalia Smolina | 10 | 26 | 321 |
O. P. Rotar | 9 | 44 | 324 |
Lubov Mitrofanova | 9 | 43 | 681 |
Elena Ignatieva | 8 | 18 | 201 |
Polina V. Popova | 8 | 27 | 253 |
Lyudmila Korostovtseva | 8 | 53 | 228 |