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Showing papers by "Fifth Affiliated Hospital of Xinjiang Medical University published in 2010"

Journal Article•DOI•
Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters

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Tao Wang1, Su-Xia Han2, Su-Xia Han1, Shang-Fu Zhang1, Yun-Ye Ning1, Lei Chen1, Ya-Juan Chen1, Guang-Ming He1, Dan Xu, Jin An1, Ting Yang1, Xiaohong Zhang1, Fuqiang Wen1 •
Sichuan University1, Fifth Affiliated Hospital of Xinjiang Medical University2
31 Mar 2010-Respiratory Research
TL;DR: The results show that chronic cigarette smoke exposure significantly induced elevation of right ventricular systolic pressures (RVSP) and medial hypertrophy of pulmonary arterioles in hamsters, concurrent with an increase of chymase activity and synthesis in the lung.
Abstract: Background Cigarette smoking is an important risk factor for pulmonary arterial hypertension (PAH) in chronic obstructive pulmonary disease (COPD). Chymase has been shown to function in the enzymatic production of angiotensin II (AngII) and the activation of transforming growth factor (TGF)-β1 in the cardiovascular system. The aim of this study was to determine the potential role of chymase in cigarette smoke-induced pulmonary artery remodeling and PAH.

34 citations

Journal Article•DOI•
Cardiac multi-marker strategy for effective diagnosis of acute myocardial infarction.

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Qin Xu1, Cangel Pui-yee Chan2, Xiao-yao Cao, Peng Peng1, Maisumu Mahemuti1, Qi Sun1, Kwan Yee Cheung, Wai-sze Ip2, Xin-rong Zhou1, Ge-yang Hu1, Xiao-feng Zhang, Jiasharete Jielile1, Yao-dong Li1, Rong Ren3, Jan F. C. Glatz4, Reinhard Renneberg2 •
First Affiliated Hospital of Xinjiang Medical University1, Hong Kong University of Science and Technology2, Fifth Affiliated Hospital of Xinjiang Medical University3, Maastricht University4
11 Nov 2010-Clinica Chimica Acta
TL;DR: A cardiac panel consisting of H-FABP and troponin is recommended and was found to have higher diagnostic accuracy than cTnI and CK-MB in patients admitted within 3h.

15 citations