Jawaharlal Nehru Technological University, Hyderabad

About: Jawaharlal Nehru Technological University, Hyderabad is a education organization based out in Hyderabad, India. It is known for research contribution in the topics: Cluster analysis & Control theory. The organization has 3956 authors who have published 5277 publications receiving 48435 citations. The organization is also known as: JNTU Hyderabad & Nagarjuna Sagar Engineering College.

Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: application for a pharmacokinetic study.

Abstract: A sensitive and reliable high-performance liquid chromatography–mass spectrometry (LC–MS/MS) was developed and validated for simultaneous quantification IC87114, roflumilast (RFM), and its active metabolite roflumilast N-oxide (RFN) using tolbutamide as an internal standard. The analytes were extracted by using liquid–liquid extraction and separated on a reverse phase C18 column (50 mm × 3 mm i.d., 4.6 µ) using methanol: 2 mM ammonium acetate buffer, pH 4.0 as mobile phase at a flow rate 1 mL/min in gradient mode. Selective reaction monitoring was performed using the transitions m/z 398.3 > 145.9, 403.1 >186.9, 419.1 > 187.0 and 271.1 > 155.0 to quantify quantification IC87114, RFM, RFN and tolbutamide, respectively. The method was validated over the concentration range of 0.1–60 ng.mL−1 for RFM and RFN and 6 to 2980 ng.mL−1 for IC87114. Intra- and inter-day accuracy and precision of validated method were within the acceptable limits of 0.99 for all analytes. The quantitation method was successfully applied for simultaneous estimation of IC87114, RFM and RFN in a pharmacokinetic drug–drug interaction study in Wistar rats. Copyright © 2012 John Wiley & Sons, Ltd.

Reputation-based secure routing protocol in mobile ad-hoc network using Jaya Cuckoo optimization

Abstract: The advancements in Mobile Ad-hoc Network (MANET) are suitable to wide applications, which involve military applications, civilian domains, and disaster recovery systems. It is assumed that the nod...

Silica sulfuric acid: A simple, efficient, and reusable heterogeneous catalyst for the one-pot synthesis of aryl-14H-dibenzo[ a,j ]xanthenes under conventional heating and solvent-free conditions

Abstract: A novel approach towards the one-pot synthesis of aryl-14H-dibenzo[a,j]xanthenes is described from a known reaction between substituted aldehydes and β-naphthol in the presence of heterogeneous catalyst silica sulfuric acid under conventional heating as well as solvent-free conditions to afford good to excellent yields. The catalyst is reusable; it can be used several times without any decrease in the product yield.