Institution
Ludwig Maximilian University of Munich
Education•Munich, Germany•
About: Ludwig Maximilian University of Munich is a education organization based out in Munich, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 83850 authors who have published 161504 publications receiving 5792158 citations. The organization is also known as: LMU & University of Munich.
Topics: Population, Transplantation, Medicine, Gene, Cancer
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated here that LPS-induced NO synthesis was increased after blocking the binding of endogenous ANP by a receptor antagonist, suggesting ANP as a new autocrine macrophage factor regulating NO synthesis both transcriptionally and post-transcriptionally.
127 citations
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01 Aug 2000127 citations
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TL;DR: Alb3 homologs Oxa1 and YidC have been shown to be required for the integration of newly synthesized proteins into membranes, but although Alb3.1p is not required for integration of the plastid-encoded photosystem II core subunit D1 into the thylakoid membrane of Chlamydomonas reinhardtii, the insertion of D 1 into functional photosynthetic complexes is retarded in the Alb32 deletion mutant ac29.
Abstract: Alb3 homologs Oxa1 and YidC have been shown to be required for the integration of newly synthesized proteins into membranes. Here, we show that although Alb3.1p is not required for integration of the plastid-encoded photosystem II core subunit D1 into the thylakoid membrane of Chlamydomonas reinhardtii, the insertion of D1 into functional photosystem II complexes is retarded in the Alb3.1 deletion mutant ac29. Alb3.1p is associated with D1 upon its insertion into the membrane, indicating that Alb3.1p is essential for the efficient assembly of photosystem II. Furthermore, levels of nucleus-encoded light-harvesting proteins are vastly reduced in ac29; however, the remaining antenna systems are still connected to photosystem II reaction centers. Thus, Alb3.1p has a dual function and is required for the accumulation of both nucleus- and plastid-encoded protein subunits in photosynthetic complexes of C. reinhardtii.
127 citations
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TL;DR: The present study aimed to assess the outcome of extended pancreatectomy for borderline resectable and locally advanced pancreatic cancer.
Abstract: Background
In the recent International Study Group of Pancreatic Surgery (ISGPS) consensus on extended pancreatectomy, several issues on perioperative outcome and long-term survival remained unclear. Robust data on outcomes are sparse. The present study aimed to assess the outcome of extended pancreatectomy for borderline resectable and locally advanced pancreatic cancer.
Methods
A consecutive series of patients with primary pancreatic adenocarcinoma undergoing extended pancreatectomies, as defined by the new ISGPS consensus, were compared with patients who had a standard pancreatectomy. Univariable and multivariable analysis was performed to identify risk factors for perioperative mortality and characteristics associated with survival. Long-term outcome was assessed by means of Kaplan–Meier analysis.
Results
The 611 patients who had an extended pancreatectomy had significantly greater surgical morbidity than the 1217 patients who underwent a standard resection (42·7 versus 34·2 per cent respectively), and higher 30-day mortality (4·3 versus 1·8 per cent) and in-hospital mortality (7·5 versus 3·6 per cent) rates. Operating time of 300 min or more, extended total pancreatectomy, and ASA fitness grade of III or IV were associated with increased in-hospital mortality in multivariable analysis, whereas resections involving the colon, portal vein or arteries were not. Median survival and 5-year overall survival rate were reduced in patients having extended pancreatectomy compared with those undergoing a standard resection (16·1 versus 23·6 months, and 11·3 versus 20·6 per cent, respectively). Older age, G3/4 tumours, two or more positive lymph nodes, macroscopic positive resection margins, duration of surgery of 420 min or above, and blood loss of 1000 ml or more were independently associated with decreased overall survival.
Conclusion
Extended resections are associated with increased perioperative morbidity and mortality, particularly when extended total pancreatectomy is performed. Favourable long-term outcome is achieved in some patients.
127 citations
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TL;DR: The development of the triactinomyxon stage of Myxobolus cerebralis and release of mature spores from Tubifex tubifex were shown to be temperature dependent and M. cerebralis did not appear to be as short-lived as previously reported.
127 citations
Authors
Showing all 84483 results
Name | H-index | Papers | Citations |
---|---|---|---|
Albert Hofman | 267 | 2530 | 321405 |
Paul M. Ridker | 233 | 1242 | 245097 |
Rudolf Jaenisch | 206 | 606 | 178436 |
David Miller | 203 | 2573 | 204840 |
Dennis J. Selkoe | 177 | 607 | 145825 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Stanley B. Prusiner | 168 | 745 | 97528 |
Philippe Froguel | 166 | 820 | 118816 |
James G. Fujimoto | 165 | 1115 | 116451 |
Stephen L. Buchwald | 164 | 1087 | 90994 |
Carlos Bustamante | 161 | 770 | 106053 |
Jens J. Holst | 160 | 1536 | 107858 |
Kaj Blennow | 160 | 1845 | 116237 |
Christian Gieger | 157 | 617 | 113657 |
Jerome I. Rotter | 156 | 1071 | 116296 |