Showing papers by "Ludwig Maximilian University of Munich published in 1999"

A theory of fairness, competition and cooperation

Abstract: There is strong evidence that people exploit their bargaining power in competitivemarkets butnot inbilateral bargainingsituations. Thereisalsostrong evidence that people exploit free-riding opportunities in voluntary cooperation games. Yet, when they are given the opportunity to punish free riders, stable cooperation is maintained, although punishment is costly for those who punish. This paper asks whether there is a simple common principle that can explain this puzzling evidence. We show that if some people care about equity the puzzles can be resolved. It turns out that the economic environment determines whether the fair types or the selesh types dominate equilibrium behavior.

OPTICS: ordering points to identify the clustering structure

Abstract: Cluster analysis is a primary method for database mining. It is either used as a stand-alone tool to get insight into the distribution of a data set, e.g. to focus further analysis and data processing, or as a preprocessing step for other algorithms operating on the detected clusters. Almost all of the well-known clustering algorithms require input parameters which are hard to determine but have a significant influence on the clustering result. Furthermore, for many real-data sets there does not even exist a global parameter setting for which the result of the clustering algorithm describes the intrinsic clustering structure accurately. We introduce a new algorithm for the purpose of cluster analysis which does not produce a clustering of a data set explicitly; but instead creates an augmented ordering of the database representing its density-based clustering structure. This cluster-ordering contains information which is equivalent to the density-based clusterings corresponding to a broad range of parameter settings. It is a versatile basis for both automatic and interactive cluster analysis. We show how to automatically and efficiently extract not only 'traditional' clustering information (e.g. representative points, arbitrary shaped clusters), but also the intrinsic clustering structure. For medium sized data sets, the cluster-ordering can be represented graphically and for very large data sets, we introduce an appropriate visualization technique. Both are suitable for interactive exploration of the intrinsic clustering structure offering additional insights into the distribution and correlation of the data.

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Abstract: Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical trials, possibly because these cytokines are early mediators in pathogenesis. Here a potential late mediator of lethality is identified and characterized in a mouse model. High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1. Mice showed increased serum levels of HMG-1 from 8 to 32 hours after endotoxin exposure. Delayed administration of antibodies to HMG-1 attenuated endotoxin lethality in mice, and administration of HMG-1 itself was lethal. Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target.

World Risk Society

Abstract: 1. Introduction: The Cosmopolitan Manifesto. 2. World Risk Society as Cosmopolitan Society? Ecological Questions in a Framework of Manufactured Uncertainties. 3. From Industrial Society to the Risk Society: Questions of Survival, Social Structure and Ecological Enlightenment. 4. Risk Society and the Welfare State. 5. Subpolitics: Ecology and the Disintegration of Institutional Power. 6. Knowledge or Unawareness: Two Perspectives on a Reflexive Modernizationa . 7. Risk Society Revisited: Theory, Politics, Critiques and Research Programmes. Notes. References. Index.

The physiological equivalent temperature - a universal index for the biometeorological assessment of the thermal environment.

Abstract: With considerably increased coverage of weather information in the news media in recent years in many countries, there is also more demand for data that are applicable and useful for everyday life. Both the perception of the thermal component of weather as well as the appropriate clothing for thermal comfort result from the integral effects of all meteorological parameters relevant for heat exchange between the body and its environment. Regulatory physiological processes can affect the relative importance of meteorological parameters, e.g. wind velocity becomes more important when the body is sweating. In order to take into account all these factors, it is necessary to use a heat-balance model of the human body. The physiological equivalent temperature (PET) is based on the Munich Energy-balance Model for Individuals (MEMI), which models the thermal conditions of the human body in a physiologically relevant way. PET is defined as the air temperature at which, in a typical indoor setting (without wind and solar radiation), the heat budget of the human body is balanced with the same core and skin temperature as under the complex outdoor conditions to be assessed. This way PET enables a layperson to compare the integral effects of complex thermal conditions outside with his or her own experience indoors. On hot summer days, for example, with direct solar irradiation the PET value may be more than 20 K higher than the air temperature, on a windy day in winter up to 15 K lower.

Growing season extended in Europe

Abstract: Changes in phenology (seasonal plant and animal activity driven by environmental factors) from year to year may be a sensitive and easily observable indicator of changes in the biosphere. We have analysed data from more than 30 years of observation in Europe, and found that spring events, such as leaf unfolding, have advanced by 6 days, whereas autumn events, such as leaf colouring, have been delayed by 4.8 days. This means that the average annual growing season has lengthened by 10.8 days since the early 1960s. These shifts can be attributed to changes in air temperature.

Citation Frequency and the Value of Patented Innovation

Abstract: Through a survey, economic value estimates were obtained on 962 inventions made in the United States and Germany and on which German patent renewal fees were paid to full-term expiration in 1995. A search of subsequent U.S. and German patents yielded a count of citations to those patents. Patents renewed to full term were significantly more valuable than patents allowed to expire before their full term. The higher an invention's economic value estimate was, the more the relevant patent was subsequently cited.

Culture specific and cross-culturally generalizable implicit leadership theories: Are attributes of charismatic/transformational leadership universally endorsed?

Abstract: This study focuses on culturally endorsed implicit theories of leadership (CLTs). Although cross-cultural research emphasizes that different cultural groups likely have different conceptions of what leadership should entail, a controversial position is argued here: namely that attributes associated with charismatic/transformational leadership will be universally endorsed as contributing to outstanding leadership. This hypothesis was tested in 62 cultures as part of the Global Leadership and Organizational Behavior Effectiveness (GLOBE) Research Program. Universally endorsed leader attributes, as well as attributes that are universally seen as impediments to outstanding leadership and culturally contingent attributes are presented here. The results support the hypothesis that specific aspects of charismatic/transformational leadership are strongly and universally endorsed across cultures.

How Strong Is a Covalent Bond

Abstract: The rupture force of single covalent bonds under an external load was measured with an atomic force microscope (AFM). Single polysaccharide molecules were covalently anchored between a surface and an AFM tip and then stretched until they became detached. By using different surface chemistries for the attachment, it was found that the silicon-carbon bond ruptured at 2.0 ± 0.3 nanonewtons, whereas the sulfur-gold anchor ruptured at 1.4 ± 0.3 nanonewtons at force-loading rates of 10 nanonewtons per second. Bond rupture probability calculations that were based on density functional theory corroborate the measured values.

Uniform asymptotics for polynomials orthogonal with respect to varying exponential weights and applications to universality questions in random matrix theory

Abstract: We consider asymptotics for orthogonal polynomials with respect to varying exponential weights wn(x)dx = e−nV(x)dx on the line as n ∞. The potentials V are assumed to be real analytic, with sufficient growth at infinity. The principle results concern Plancherel-Rotach-type asymptotics for the orthogonal polynomials down to the axis. Using these asymptotics, we then prove universality for a variety of statistical quantities arising in the theory of random matrix models, some of which have been considered recently in [31] and also in [4]. An additional application concerns the asymptotics of the recurrence coefficients and leading coefficients for the orthonormal polynomials (see also [4]). The orthogonal polynomial problem is formulated as a Riemann-Hilbert problem following [19, 20]. The Riemann-Hilbert problem is analyzed in turn using the steepest-descent method introduced in [12] and further developed in [11, 13]. A critical role in our method is played by the equilibrium measure dμV for V as analyzed in [8]. © 1999 John Wiley & Sons, Inc.

Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood.

Abstract: BACKGROUND: Little is known about the prevalence of atopic eczema outside Northern Europe. OBJECTIVES: We sought to describe the magnitude and variation in the prevalence of atopic eczema symptoms throughout the world. METHODS: A cross-sectional questionnaire survey was conducted on random samples of schoolchildren aged 6 to 7 years and 13 to 14 years from centers in 56 countries throughout the world. Those children with a positive response to being questioned about the presence of an itchy relapsing skin rash in the last 12 months that had affected their skin creases were considered to have atopic eczema. Children whose atopic eczema symptoms resulted in sleep disturbance for 1 or more nights per week were considered to have severe atopic eczema. RESULTS: Complete data was available for 256,410 children aged 6 to 7 years in 90 centers and 458,623 children aged 13 to 14 years in 153 centers. The prevalence range for symptoms of atopic eczema was from less than 2% in Iran to over 16% in Japan and Sweden in the 6 to 7 year age range and less than 1% in Albania to over 17% in Nigeria for the 13 to 14 year age range. Higher prevalences of atopic eczema symptoms were reported in Australasia and Northern Europe, and lower prevalences were reported in Eastern and Central Europe and Asia. Similar patterns were seen for symptoms of severe atopic eczema. CONCLUSIONS: Atopic eczema is a common health problem for children and adolescents throughout the world. Symptoms of atopic eczema exhibit wide variations in prevalence both within and between countries inhabited by similar ethnic groups, suggesting that environmental factors may be critical in determining disease expression. Studies that include objective skin examinations are required to confirm these findings.

Breast feeding and obesity: cross sectional study

Abstract: Objective To assess the impact of breast feeding on the risk of obesity and risk of being overweight in children at the time of entry to school. Design Cross sectional survey Setting Bavaria, southern Germany. Methods Routine data were collected on the height and weight of 134 577 children participating in the obligatory health examination at the time of school entry in Bavaria. In a subsample of 13 345 children, early feeding, diet, and lifestyle factors were assessed using responses to a questionnaire completed by parents. Subjects 9357 children aged 5 and 6 who had German nationality.

Orthogonal polarization spectral imaging: a new method for study of the microcirculation.

Abstract: Different disease states, including diabetes, hypertension and coronary heart disease, produce distinctive microvascular pathologies So far, imaging of the human microcirculation has been limited to vascular beds in which the vessels are visible and close to the surface (for example, nailfold, conjunctiva) We report here on orthogonal polarization spectral (OPS) imaging, a new method for imaging the microcirculation using reflected light that allows imaging of the microcirculation noninvasively through mucus membranes and on the surface of solid organs In OPS imaging, the tissue is illuminated with linearly polarized light and imaged through a polarizer oriented orthogonal to the plane of the illuminating light Only depolarized photons scattered in the tissue contribute to the image The optical response of OPS imaging is linear and can be used for reflection spectrophotometry over the wide range of optical density typically achieved by transmission spectrophotometry A comparison of fluorescence intravital microscopy with OPS imaging in the hamster demonstrated equivalence in measured physiological parameters under control conditions and after ischemic injury OPS imaging produced high-contrast microvascular images in people from sublingual sites and the brain surface that appear as in transillumination The technology can be implemented in a small optical probe, providing a convenient method for intravital microscopy on otherwise inaccessible sites and organs in the awake subject or during surgery for research and for clinical diagnostic applications At present, the use of microvascular imaging in diagnosis and treatment of human disease is limited Use has been made of nailfold capillaroscopy in the diagnosis and treatment of peripheral vascular diseases, diabetes and hematological disorders 1‐3 Problems with movement have restricted the use of the bulbar conjunctiva for clinical applications in opthalmology 4‐6 Other lo

Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study.

Abstract: ObjectiveTo investigate the effects of stress doses of hydrocortisone on the duration of vasopressor therapy in human septic shock.DesignProspective, randomized, double-blind, single-center study.SettingTwenty-bed multidiscipllnary intensive care unit in a 1400-bed university hospital.PatientsForty

Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans

Abstract: 1Blockade of uptake carriers of γ-aminobutyric acid (GABA) has been shown to modulate inhibition in cortical slices of experimental animals, although little is known about this mechanism in vivo and, in particular, in humans. 2The effects of blockade of GABA uptake were studied using transcranial magnetic stimulation (TMS) in humans. In eight healthy volunteers several measures of cortical excitation and inhibition were obtained before and ≈2 h after ingestion of 5-15 mg of tiagabine (TGB). 3After TGB ingestion, the duration of the TMS-induced silent period observable in the electromyogram of the voluntarily contracted target muscle was prolonged. Similarly, paired-pulse inhibition of the motor-evoked potential (MEP), as tested by delivering two magnetic shocks of equal suprathreshold intensities at 160 ms interstimulus interval (ISI), was more pronounced. In apparent contradistinction, paired-pulse inhibition of the MEPs produced by a subthreshold conditioning stimulus delivered 3 ms prior to a suprathreshold stimulus was reduced. Paired-pulse facilitation elicited by the same double-shock protocol at an ISI of 10 ms was increased. 4The prolongation of the GABAB receptor-mediated component of the inhibitory postsynaptic potential observed with TGB in in vitro studies probably underlies the increase in cortical silent period duration. The reduction of the paired-pulse inhibition at 3 ms, in turn, probably reflects inhibition of GABAA receptor-mediated inhibition via presynaptic GABAB receptors. 5These data provide in vivo evidence of differential modulation of cortical inhibition by blockade of GABA uptake. Presynaptic GABA autoreceptors may be involved in modulating cortical inhibition in the human motor cortex.

Transgenerational induction of defences in animals and plants

Abstract: Predators are potent agents of natural selection in biological communities. Experimental studies have shown that the introduction of predators can cause rapid evolution of defensive morphologies and behaviours in prey1,2,3,4,5 and chemical defences in plants6,7. Such defences may be constitutively expressed (phenotypically fixed) or induced when predators initially attack8,9,10. Here we show that non-lethal exposure of an animal to carnivores, and a plant to a herbivore, not only induces a defence, but causes the attacked organisms to produce offspring that are better defended than offspring from unthreatened parents. This transgenerational effect, referred to as a maternally induced defence, is in contrast to the more common defences induced in single individuals within a generation. Transgenerational induction of defences is a new level of phenotypic plasticity across generations that may be an important component of predator–prey interactions.

Strong asymptotics of orthogonal polynomials with respect to exponential weights

Abstract: We consider asymptotics of orthogonal polynomials with respect to weights w(x)dx= e Q(x) dx on the real line, where Q(x)=∑ 2m k=0 qkx k , q2m> 0, denotes a polynomial of even order with positive leading coefficient. The orthogonal polynomial problem is formulated as a Riemann-Hilbert problem following [22, 23]. We employ the steepest-descent-type method introduced in [18] and further developed in [17, 19] in order to obtain uniform Plancherel-Rotach-type asymptotics in the entire complex plane, as well as asymptotic formulae for the zeros, the leading coefficients, and the recurrence coefficients of the orthogonal polynomials. c 1999 John Wiley & Sons, Inc.

Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery

Abstract: Background Changes in acid-base balance caused by infusion of a 0.9% saline solution during anesthesia and surgery are poorly characterized. Therefore, the authors evaluated these phenomena in a dose-response study. Methods Two groups of 12 patients each who were undergoing major intraabdominal gynecologic surgery were assigned randomly to receive 0.9% saline or lactated Ringer's solution in a dosage of 30 ml x kg(-1) x h(-1). The pH, arterial carbon dioxide tension, and serum concentrations of sodium, potassium, chloride, lactate, and total protein were measured in 30-min intervals. The serum bicarbonate concentration was calculated using the Henderson-Hasselbalch equation and also using the Stewart approach from the strong ion difference and the amount of weak plasma acid. The strong ion difference was calculated as serum sodium + serum potassium - serum chloride - serum lactate. The amount of weak plasma acid was calculated as the serum total protein concentration in g/dl x 2.43. Results Infusion of 0.9% saline, but not lactated Ringer's solution, caused a metabolic acidosis with hyperchloremia and a concomitant decrease in the strong ion difference. Calculating the serum bicarbonate concentration using the Henderson-Hasselbalch equation or the Stewart approach produced equivalent results. Conclusions Infusion of approximately 30 ml x kg(-1) x h(-1) saline during anesthesia and surgery inevitably leads to metabolic acidosis, which is not observed after administration of lactated Ringer's solution. The acidosis is associated with hyperchloremia.

Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry.

Abstract: Background and Methods It is uncertain whether mortality rates among patients who have undergone bone marrow transplantation return to the level of the mortality rates of the general population. We analyzed the characteristics of 6691 patients listed in the International Bone Marrow Transplant Registry. All the patients were free of their original disease two years after allogeneic bone marrow transplantation. Mortality rates in this cohort were compared with those of an age-, sex-, and nationality-matched general population. Cox proportional-hazards regression was used to identify risk factors for death more than two years after transplantation (late death). Results Among patients who were free of disease two years after transplantation, the probability of living for five more years was 89 percent (95 percent confidence interval, 88 to 90 percent). Among patients who underwent transplantation for aplastic anemia, the risk of death by the sixth year after transplantation did not differ significantly from ...

Development of the EURO-D scale--a European, Union initiative to compare symptoms of depression in 14 European centres.

Abstract: BACKGROUND In an 11-country European collaboration, 14 population-based surveys included 21,724 subjects aged > or = 65 years. Most participating centres used the Geriatric Mental State (GMS), but other measures were also used. AIMS To derive from these instruments a common depression symptoms scale, the EURO-D, to allow comparison of risk factor profiles between centres. METHOD Common items were identified from the instruments. Algorithms for fitting items to GMS were derived by observation of item correspondence or expert opinion. The resulting 12-item scale was checked for internal consistency, criterion validity and uniformity of factor-analytic profile. RESULTS The EURO-D is internally consistent, capturing the essence of its parent instrument. A two-factor solution seemed appropriate: depression, tearfulness and wishing to die loaded on the first factor (affective suffering), and loss of interest, poor concentration and lack of enjoyment on the second (motivation). CONCLUSIONS The EURO-D scale should permit valid comparison of risk-factor associations between centres, even if between-centre variation remains difficult to attribute.

3D Shape Histograms for Similarity Search and Classification in Spatial Databases

Abstract: Classification is one of the basic tasks of data mining in modern database applications including molecular biology, astronomy, mechanical engineering, medical imaging or meteorology The underlying models have to consider spatial properties such as shape or extension as well as thematic attributes We introduce 3D shape histograms as an intuitive and powerful similarity model for 3D objects Particular flexibility is provided by using quadratic form distance functions in order to account for errors of measurement, sampling, and numerical rounding that all may result in small displacements and rotations of shapes For query processing, a general filter-refinement architecture is employed that efficiently supports similarity search based on quadratic forms An experimental evaluation in the context of molecular biology demonstrates both, the high classification accuracy of more than 90% and the good performance of the approach

Single molecule force spectroscopy by AFM indicates helical structure of poly(ethylene-glycol) in water

Abstract: We elongated individual poly(ethylene-glycol) (PEG) molecules tethered at one end to an AFM cantilever. We observed the resistive force as a function of elongation in different solvents. In all cases the molecular response was found to be fully reversible and thus in thermodynamic equilibrium. In hexadecane the stretched PEG acts like an ideal entropy spring and can be well described as a freely jointed chain. In water we observed marked deviations in the transition region from entropic to enthalpic elasticity, indicating the deformation of a supra-structure within the polymer. An analysis based on elastically coupled Markovian two-level systems agrees well with recent ab initio calculations predicting that PEG in water forms a non-planar supra-structure which is stabilized by water bridges. We obtained a binding free energy of 3.0±0.3 kT.