Showing papers by "Medical University of Varna published in 1999"
TL;DR: It is suggested that histamine, which participates in the control of vigilance, sleep, and wakefulness, as well as in the modulation of circadian rhythmicity, may play a role in the development of sleep disturbances in rats with PCA.
17 citations
TL;DR: It is highlighted the possibility that neuroimmune mechanisms, including the participation of neurotrophic factors and immune cells, may also be involved in the process of atherogenesis.
Abstract: Although "many roads lead to atheroma", the prevailing hypothesis at present is the Russell Ross` response-to-injury hypothesis, which states that atherosclerosis is an inflammatory disease that involves several aspects of wound healing. It is noteworthy that, emphasized by the current studies of neurotrophic factors and nerve-immune cell interactions, neuroimmune mechanisms are increasingly implicated in the pathogenesis of a number of inflammatory diseases. Here we highlight the possibility that neuroimmune mechanisms, including the participation of neurotrophic factors and immune cells, may also be involved in the process of atherogenesis. Biomedical Reviews 1999; 10: 37-44.
6 citations
3 citations
TL;DR: The nerve growth factor has been discovered by Rita Levi-Montalcini in the early 1950s and an increasingly stable orientation of the scientific community towards the human beings, including a more outlined clinical research policy, has been emerging.
Abstract: The nerve growth factor (NGF) has been discovered by Rita Levi-Montalcini in the early 1950s. This paradigmic cell growth factor has gradually attracted the attention of many investigators from all over the world. In the very beginning, experimental research prevailed taking into consideration the still rather fundamental approach to the possible role of NGF and the subsequently discovered other neurotrophic factors in the living organism. Later on, an increasingly stable orientation of the scientific community towards the human beings, including a more outlined clinical research policy, has been emerging. Biomedical Reviews 1999; 10: 107-110.
1 citations
TL;DR: With this special volume of Biomedical Reviews the authors bring to you an update of Nerve Growth Factor in Health and Disease.
Abstract: With this special volume of Biomedical Reviews we bring to you an update of Nerve Growth Factor in Health and Disease. Biomedical Reviews 1999; 10: 1-2.
1 citations
TL;DR: In this article, the authors highlight the involvement of cholesterol, lipoproteins and lipoprotein receptors in the neuronal development and of neurotrophic factors in the lipid and glucose metabolism, and argue that in addition to its implication in neurodegenerative diseases such as Alzheimer's disease, neurolipidology may have wide-ranging potential within a variety of nonneuronal fields, including cardiovascular disease, particularly, atherosclerosis and related disorders.
Abstract: Here we highlight current data of the involvement of cholesterol, lipoproteins and lipoprotein receptors in the neuronal development and of neurotrophic factors in the lipid and glucose metabolism. We term these interactions neurolipidology. And argue that in addition to its implication in neurodegenerative diseases such as Alzheimer`s disease, neurolipidology may have wide-ranging potential within a variety of nonneuronal fields, including cardiovascular disease, particularly, atherosclerosis and related disorders. Biomedical Reviews 1999; 10: 111-113.
01 Jan 1999
TL;DR: The Tc-99m-HMPAO SPECT method provides an adequate assessment of CBF autoregulation and abnormal PI after exercise stress were detected in stage I and in stage II of HT.
Abstract: The study aims at assessing the regional cerebral blood flow (rCBF) in uncomplicated hypertension (HT). We investigated 21 patients in stage I and 11 patients in stage II of HT. Tc-99m-HMPAO SPECT was performed at rest and after exercise stress. The right to left ratio values, perfusion indices (PI), were calculated in 10 symmetric sectorial areas of 3 transversal slices. The PI at rest did not differ from the referent values, except for 4 patients in the II stage of HT. Abnormal PI after exercise stress were detected in stage I (n=17) and in stage II (n=10) . The method provides an adequate assessment of CBF autoregulation.