Institution
Pilgrim Psychiatric Center
Healthcare•Brentwood, New York, United States•
About: Pilgrim Psychiatric Center is a healthcare organization based out in Brentwood, New York, United States. It is known for research contribution in the topics: Schizophrenia & Psychosis. The organization has 41 authors who have published 39 publications receiving 1629 citations. The organization is also known as: Pilgrim State Hospital.
Papers
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TL;DR: Clients with schizophrenia who have higher levels of cognitive impairment may require greater amounts of vocational support than those with lower levels of impairment and a variety of rehabilitation strategies may be required to improve vocational outcomes and reduce the amount of supported employment services needed by clients with schizophrenia.
Abstract: OBJECTIVES: This study examined the relationships of measures of cognitive functioning and psychiatric symptoms with work outcomes and use of vocational services for clients with schizophrenia in a supported employment program. METHODS: Thirty clients who were newly enrolled in a supported employment program were evaluated with cognitive and symptom measures at program entry and two years later. The clients' amounts of competitive work, wages earned, on-job support, and contact with employment specialists during the two-year follow-up period were documented. RESULTS: Predictors of clients' work outcomes included previous work history, amount of government entitlement income received, severity of negative symptoms, involvement in sheltered work activity at baseline, and level of cognitive functioning, including scores on measures of executive functioning and verbal learning and memory. The amounts of on-job support and contact with employment specialists were predicted by the cognitive domains of executive...
241 citations
TL;DR: A cholinergic approach to ameliorating the cognitive dysfunction of schizophrenia appears viable, with some preliminary data to support the efficacy of combined acetylcholinesterase inhibitors and allosteric potentiators of the nicotinic receptor.
Abstract: Rationale
Alterations in the central cholinergic system of patients with schizophrenia such as reduced numbers of muscarinic and nicotinic receptors in the cortex and hippocampus may contribute to the cognitive impairment of schizophrenia. Therefore, pharmacological treatments that enhance central cholinergic function may be useful as cognitive enhancers in schizophrenia.
175 citations
TL;DR: It is possible that nicotinic receptor desensitization produced by chronic tobacco use in schizophrenic patients rendered their Nicotinic receptors refractory to the effects of increased agonist activity produced by donepezil.
171 citations
TL;DR: Exploratory non-parametric statistics revealed some significant and some trend differences between guanfacine and placebo on spatial working memory test performance and CPT reaction time in those subjects treated with atypical neuroleptics.
102 citations
TL;DR: The present data corroborate two previous reports of sexual dimorphism of INAH3 but provide no support for previous reports for sexual variation in other INAH.
102 citations
Authors
Showing all 41 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Joseph H. Friedman | 77 | 429 | 23014 |
| Christopher R. Bowie | 50 | 211 | 11095 |
| William Byne | 41 | 99 | 5254 |
| Leonard White | 30 | 63 | 3520 |
| Joseph I. Friedman | 29 | 50 | 11712 |
| Michael Parrella | 28 | 53 | 2808 |
| David N. Adler | 6 | 6 | 728 |
| Stephanie Bowler | 5 | 5 | 196 |
| M. F. Losonczy | 5 | 5 | 576 |
| S. Masiar | 5 | 8 | 235 |
| Thomas Coleman | 3 | 3 | 318 |
| Marguerite McCartin-Clark | 2 | 2 | 13 |
| Zeinab Elbaz | 2 | 2 | 89 |
| Isabella Kanellopoulou | 2 | 2 | 212 |
| Louis Ernesto Mora | 1 | 1 | 8 |