Purdue Pharma

About: Purdue Pharma is a company organization based out in Pickering, Ontario, Canada. It is known for research contribution in the topics: Buprenorphine & Chronic pain. The organization has 622 authors who have published 691 publications receiving 31545 citations. The organization is also known as: Purdue Pharmaceuticals L.P..

Trpv1 antagonists including amide substituent and uses thereof

Abstract: The invention relates to compounds of formula IA″ and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula IA″ or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula IA″ or a pharmaceutically acceptable derivative thereof.

Design and Synthesis of Novel Small Molecule N/OFQ Receptor Antagonists.

Abstract: Small molecule N/OFQ receptor antagonists were designed and synthesized to further investigate the therapeutic potential of N/OFQ receptor modulators. The resulting octahydrobenzimidazol-2-ones 14 and 23 show excellent antagonistic activity towards both N/OFQ and mu receptors with high affinity to the human N/OFQ receptor.

Novel sodium channel blocking peptides and the use thereof

Abstract: The present invention relates to C-terminal modified Protoxin II peptides that selectively inhibit the Nav1.7 sodium channel; the present invention also relates to pharmaceutical compositions useful for prophylactic or therapeutic treatment of a disorder responsive to the blockade of sodium ion channels, especially Nav1.7 sodium ion channels; the present invention further provides methods of treating a disorder responsive to the blockade of sodium channels, and particularly Nav1.7 sodium channels, in a mammal suffering from excess activity of said channels.

The “Five-Minute” Mental Status Examination of Persons with Pain

Abstract: The mental status examination (MSE) is just that – a set of processes that systematically examine various aspects of a person’s mental functioning – in essence, a physical examination of the mind. A complete MSE constitutes a distinct portion of a complete psychiatric assessment. In practice, whether in psychiatry or other specialties, the MSE can be less comprehensive than a complete MSE, according to the clinical setting. MSEs can be partial – focusing only a particular aspect, such as mood or intelligence, or can be exhaustive.