Institution
Purdue Pharma
Company•Pickering, Ontario, Canada•
About: Purdue Pharma is a company organization based out in Pickering, Ontario, Canada. It is known for research contribution in the topics: Buprenorphine & Chronic pain. The organization has 622 authors who have published 691 publications receiving 31545 citations. The organization is also known as: Purdue Pharmaceuticals L.P..
Topics: Buprenorphine, Chronic pain, Oxycodone, Hydrocodone, Controlled release
Papers published on a yearly basis
Papers
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TL;DR: In the search for more efficacious drugs to treat neuropathic pain states, a series of phenoxyphenyl pyridines was designed based on 4-(4-flurophenoxy)benzaldehyde semicarbazone and several potent state-dependent sodium channel inhibitors were identified.
Abstract: In the search for more efficacious drugs to treat neuropathic pain states, a series of phenoxyphenyl pyridines was designed based on 4-(4-flurophenoxy)benzaldehyde semicarbazone. Through variation of the substituents on the pyridine ring, several potent state-dependent sodium channel inhibitors were identified. From these compounds, 23 dose dependently reversed tactile allodynia in the Chung model of neuropathic pain. Administered orally at 10 mg/kg the level of reversal was ca. 50%, comparable to the effect of carbamazepine administered orally at 100 mg/kg.
56 citations
TL;DR: A structurally biased chemical library of pyridazinylpiperazine analogs was prepared in an effort to improve the pharmaceutical and pharmacological profile of the lead compound N-(4-tertiarybutylphenyl)-4-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide (BCTC).
55 citations
TL;DR: In this paper, NIR analytical methods can be validated to meet the requirement of demonstrating that it is suitable for the analysis of the materials for which it is being used, and the authors apply previously described protocols for NIR methods to analyze two types of pharmaceutical products and show that for these products, NIR is suitable as an alternate analytical method for assay and for content uniformity.
54 citations
TL;DR: How, when, and why animal models of pain are used as one of the many experimental tools used to gain better understanding of target mechanisms and rank-order compounds in the iterative process of establishing structure-activity relationships (SAR) is highlighted.
54 citations
TL;DR: It was demonstrated that CO2(g) sparging at a pH consistent with the fed state created an in-situ bicarbonate buffer at low concentrations, which had a significant impact on the dissolution of a basic drug such as dipyridamole.
Abstract: Purpose. The aim of this study was to examine if sparging with CO2(g) could be used to establish stable biorelevant bicarbonate buffers, in aqueous medium, for use in dissolution characterization of low-solubility ionizable drugs.
54 citations
Authors
Showing all 622 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gideon Koren | 129 | 1994 | 81718 |
| Asbjørn Mohr Drewes | 67 | 656 | 17287 |
| Hilary L. Surratt | 44 | 169 | 7586 |
| Ronald M. Burch | 42 | 108 | 5897 |
| John F. W. Keana | 41 | 234 | 6349 |
| Sui Xiong Cai | 39 | 91 | 4492 |
| Howard D. Chilcoat | 39 | 91 | 8739 |
| Sidney H. Schnoll | 37 | 88 | 5336 |
| Paul Coplan | 36 | 121 | 4149 |
| Benjamin Oshlack | 32 | 95 | 3902 |
| Nabarun Dasgupta | 30 | 100 | 3366 |
| Donald J. Kyle | 29 | 150 | 2390 |
| Nancy C. Lan | 29 | 50 | 3597 |
| Christopher D. Breder | 28 | 50 | 6748 |
| Michael F. Schneider | 27 | 53 | 4862 |