Purdue Pharma

About: Purdue Pharma is a company organization based out in Pickering, Ontario, Canada. It is known for research contribution in the topics: Buprenorphine & Chronic pain. The organization has 622 authors who have published 691 publications receiving 31545 citations. The organization is also known as: Purdue Pharmaceuticals L.P..

Methods for making 3-O protected morphinones and 3-O-protected morphinone dienol carboxylates

Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I) wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.

Abuse-deterrent dosage forms

Abstract: Abuse-deterrent dosage forms (e.g., orally administered dosage forms, transdermal dosage forms, suppositories, etc.), processes for formulating pharmaceutical dosage forms comprising an active agent susceptible to abuse (e.g., an opioid agonist, a benzodiazepine, a stimulant) such that the resulting dosage forms are abuse-deterrent are described. Also described are methods of deterring abuse of pharmaceutical dosage forms.

Acrylic Polymer Formulations

Abstract: Disclosed herein are oral solid dosage forms comprising purified neutral acrylic polymer, methods of treating a disease or condition using the same, and methods of preparing the same.

Blinded sample size adjustment

Abstract: The determination of the appropriate sample size is an important aspect of planning a clinical trial. In recent years, procedures for estimation of a nuisance parameter to adjust the sample size if necessary have been examined. Here, it is assumed that the clinical trial is conducted for the comparison of two treatments, where the observations are assumed to have normal distributions with a common unknown variance. For sample size determination, the variance is assumed known and the resulting sample size is sensitive to misspecification of the variance. An estimate of the variance, obtained while the clinical trial is ongoing, can often be used to assess the appropriateness of the assumed variance. The use of a blinded estimate of the variance to potentially adjust the sample size is examined.