Sri Padmavati Mahila Visvavidyalayam

About: Sri Padmavati Mahila Visvavidyalayam is a education organization based out in Tirumala - Tirupati, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Cloud computing. The organization has 427 authors who have published 341 publications receiving 2246 citations. The organization is also known as: Sri Padmavati University.

Role of human liver microsomes in in vitro metabolism of drugs-a review.

Abstract: Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabolism and inhibition studies. The methodology for these studies using human liver microsomes, applications of human liver microsomes, and the drugs studied by human liver microsomes are listed. Human liver microsomes represent a critical experimental model for the evaluation of drug metabolites with a high probability of clinical success.

Bioinspired green synthesis of copper oxide nanoparticles from Syzygium alternifolium (Wt.) Walp: characterization and evaluation of its synergistic antimicrobial and anticancer activity

Abstract: In recent times, nanoparticles are attributed to green nanotechnology methods to know the synergistic biological activities. To accomplish this phenomenon, present study was aimed to synthesize copper oxide nanoparticles (CuO NPs) by using Syzygium alternifolium stem bark, characterized those NPs using expository tools and to elucidate high prioritized antimicrobial and anticancer activities. Synthesized particles exhibited a color change pattern upon synthesis and affirmed its respective broad peak at 285 nm which was analyzed through UV–vis spectroscopy. FT-IR study confirmed that phenols and primary amines were mainly involved in capping and stabilization of nanoparticles. DLS and Zeta potential studies revealed narrow size of particles with greater stability. XRD studies revealed the crystallographic nature of particles with 17.2 nm average size. Microscopic analysis by using TEM revealed that particle size range from 5–13 nm and most of them were spherical in shape, non-agglomerated and poly-dispersed in condition. Antimicrobial studies of particles showed highest inhibitory activity against E. coli and T. harzianum among bacterial and fungal strains, respectively. The scope of this study is extended by examining anticancer activity of CuO NPs. This study exhibited potential anticancer activity towards MDA-MB-231 human breast cancer lines. Overall, these examinations relate that the S. alternifolium is described as efficient well-being plant and probabilistically for the design and synthesis of nanoparticles for human health. This study paves a way to better understand antimicrobial and anticancer therapeutic drug potentials of nanoparticles to design and analysis of pharmaceuticals by in vivo and in vitro approaches.

A review on optical and photoluminescence studies of RE3+ (RE=Sm, Dy, Eu, Tb and Nd) ions doped LCZSFB glasses

Abstract: Trivalent rare earth ions show interesting optical properties and such properties have high technological applications of rare earth doped materials such as energy saving lighting devices, optical displays, optical fibers, amplifiers and lasers. Among these materials rare earth ions doped glasses are of great important to optoelectronics and are widely used in fiber amplifiers and solid state high power lasers for telecommunications and light emitting diodes. Near-infrared luminescence for high power lasers is a current requirement in modern fiber optic telecommunication network and emphasis has to put in recent advances of NIR emitting materials for amplifiers, fiber lasers and waveguides. We make an effort to satisfy the above needs by preparing the LCZSFB glasses doped with Sm3+, Dy3+, Eu3+, Tb3+ and Nd3+ rare earth ions. In this review, optical properties of LCZSFB glasses doped with Sm3+, Dy3+, Eu3+, Tb3+ and Nd3+ rare earth ions and the current status of their applications is given.