St. Elizabeths Hospital

About: St. Elizabeths Hospital is a healthcare organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Dopamine & Schizophrenia. The organization has 575 authors who have published 588 publications receiving 35325 citations.

Photoreceptors in Primitive Chordates: Fine Structure, Hyperpolarizing Receptor Potentials, and Evolution

Abstract: Two species of primitive chordates have hyperpolarizing photoreceptor potentials, as vertebrates do. In Salpa the photoreceptive membrane is composed of microvilli, whereas in Amaroucium it is modified from cilia. There appears to be no functional correlation between fine structure of photoreceptive membrane and polarity of response to light.

Spinal border cell origin of the ventral spinocerebellar tract

Abstract: 1. Extra- and intracellular recording has been made in cats from the spinal border cells (SBCs) of Cooper and Sherrington (1940). The SBCs were identified by their location in the lateral part of the ventral horn in the lumbar segments 3–6 and by their antidromic invasion from the contralateral thoracic spinal cord. 2. The conduction velocity of SBC axons ranged from 40–140 m/sec with a mean of 85 m/sec. 3. Lesion experiments showed that the SBC axons ascend in the ventrolateral region of the spinal cord. 4. Of 90 SBCs tested, 85 were invaded antidromically by stimulation of the cerebellar cortex. 5. It is concluded that SBCs give rise to ventral spinocerebellar axons and suggested that they are the major source of this tract.

Seizures and Schizophrenia

Abstract: Patients with epilepsy develop psychosis or schizophrenia at a rate exceeding that expected if the two disorders were independent. Similarly, patients with schizophrenia are more prone to seizures than the general population. This excess vulnerability may be conferred by the neuropathological substrate of schizophrenia itself or by the secondary effects of the illness, including exposure to psychotropic medications that lower the seizure threshold. Neuropathological investigations into the anatomic substrate of seizures in patients with psychosis or schizophrenia are consistent with the notion that there are neurodevelopmental abnormalities involving the mesial temporal lobe. Finally, clinical recommendations for the evaluation and pharmacological management of patients with schizophrenia who have one or more seizures are described.

The Fine Structural Localization of Biogenic Monoamines in Nervous Tissue

Abstract: Publisher Summary This chapter discusses the presently available electron cytochemical methods for the analysis of biogenic monoamines, norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and emphasizes on the state of knowledge of the cytochemical reactions involved in localizations. On the basis of a large number of experimental approaches, which combine various neurocytological and histochemical observations, the association of NE-storing nerve terminals in the peripheral sympathetic nervous system is well correlated with intra-axonal small granular vesicles (SGV). Large granular vesicles (LGV) occurring in these nerves seem to play only a minor role in the storage. A nonvesicular binding material may be ubiquitously present throughout the monoamine perikaryon and portions of the axons of these cells. However, the exact composition of the SGV granule and its qualitative and quantitative relation to the monoamine are believed to be present in the vesicle, which remains to be established.