J
Joel E. Kleinman
Researcher at Johns Hopkins University
Publications - 465
Citations - 33042
Joel E. Kleinman is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Prefrontal cortex & Dorsolateral prefrontal cortex. The author has an hindex of 92, co-authored 436 publications receiving 29593 citations. Previous affiliations of Joel E. Kleinman include United States Department of Health and Human Services & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Spatio-temporal transcriptome of the human brain
Hyo Jung Kang,Yuka Imamura Kawasawa,Feng Cheng,Ying Zhu,Xuming Xu,Mingfeng Li,André M. M. Sousa,André M. M. Sousa,Mihovil Pletikos,Mihovil Pletikos,Kyle A. Meyer,Goran Sedmak,Goran Sedmak,Tobias Guennel,Yurae Shin,Matthew B. Johnson,Željka Krsnik,Simone Mayer,Sofia Fertuzinhos,Sheila Umlauf,Steven Lisgo,Alexander O. Vortmeyer,Daniel R. Weinberger,Shrikant Mane,Thomas M. Hyde,Thomas M. Hyde,Anita Huttner,Mark Reimers,Joel E. Kleinman,Nenad Sestan +29 more
TL;DR: The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.
Journal ArticleDOI
Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain
Jingshan Chen,Barbara K. Lipska,Nader D. Halim,Quang D. Ma,Mitsuyuki Matsumoto,Samer Melhem,Bhaskar Kolachana,Thomas M. Hyde,Mary M. Herman,Jose A. Apud,Michael F. Egan,Joel E. Kleinman,Daniel R. Weinberger +12 more
TL;DR: Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function.
Journal ArticleDOI
Temporal dynamics and genetic control of transcription in the human prefrontal cortex
Carlo Colantuoni,Barbara K. Lipska,Tianzhang Ye,Thomas M. Hyde,Thomas M. Hyde,Ran Tao,Jeffrey T. Leek,Elizabeth Colantuoni,Abdel G. Elkahloun,Mary M. Herman,Daniel R. Weinberger,Daniel R. Weinberger,Joel E. Kleinman +12 more
TL;DR: The temporal dynamics and genetic control of transcription in human prefrontal cortex in an extensive series of post-mortem brains from fetal development through ageing is explored, finding a wave of gene expression changes occurring during fetal development which are reversed in early postnatal life.
Journal ArticleDOI
Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
Junghyun Jo,Yixin Xiao,Alfred Xuyang Sun,Engin Cukuroglu,Hoang Dai Tran,Hoang Dai Tran,Jonathan Göke,Zi Ying Tan,Zi Ying Tan,Tzuen Yih Saw,Cheng Peow Tan,Hidayat Lokman,Young-Hwan Lee,Dong-Hoon Kim,Han Seok Ko,Seong-Oh Kim,Jae Hyeon Park,Nam-Joon Cho,Nam-Joon Cho,Thomas M. Hyde,Joel E. Kleinman,Joo Heon Shin,Daniel R. Weinberger,Eng-King Tan,Hyunsoo Shawn Je,Huck-Hui Ng +25 more
TL;DR: A method to differentiate human pluripotent stem cells into a large multicellular organoid-like structure that contains distinct layers of neuronal cells expressing characteristic markers of human midbrain is developed.
Journal ArticleDOI
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
Mingfeng Li,Gabriel Santpere,Yuka Imamura Kawasawa,Yuka Imamura Kawasawa,Oleg V. Evgrafov,Forrest O. Gulden,Sirisha Pochareddy,Susan M. Sunkin,Zhen Li,Yurae Shin,Yurae Shin,Ying Zhu,André M. M. Sousa,Donna M. Werling,Robert R. Kitchen,Hyo Jung Kang,Hyo Jung Kang,Mihovil Pletikos,Mihovil Pletikos,Jinmyung Choi,Sydney Muchnik,Xuming Xu,Daifeng Wang,Belen Lorente-Galdos,Shuang Liu,Paola Giusti-Rodríguez,Hyejung Won,Christiaan de Leeuw,Antonio F. Pardiñas,PsychENCODE Developmental Subgroup,Ming Hu,Fulai Jin,Yun Li,Michael John Owen,Michael Conlon O'Donovan,James T.R. Walters,Danielle Posthuma,Mark Reimers,Pat Levitt,Pat Levitt,Daniel R. Weinberger,Thomas M. Hyde,Joel E. Kleinman,Daniel H. Geschwind,Michael Hawrylycz,Matthew W. State,Stephen Sanders,Patrick F. Sullivan,Mark Gerstein,Ed S. Lein,James A. Knowles,Nenad Sestan +51 more
TL;DR: The generation and analysis of a variety of genomic data modalities at the tissue and single-cell levels, including transcriptome, DNA methylation, and histone modifications across multiple brain regions ranging in age from embryonic development through adulthood, reveal insights into neurodevelopment and the genomic basis of neuropsychiatric risks.