Sunrise University

TL;DR: A representative synthetic scheme and various biological activities of the heterocycles like spiropyrrolidines and oxindole moieties derivatives, especially in relation to microbial infections like cancer and tubercular, viral, HIV, bacterial, and fungal infections are presented.

TL;DR: Of the 34 novel synthesized compounds, three benzimidazoles revealed AChE inhibition with IC50<10 μM, and the relationship between lipophilicity and the chemical structures as well as their limited structure-activity relationship was discussed.

TL;DR: Pyrrolothiazolyloxindole analogues share vital pharmacological properties, considered useful in Alzheimer's disease (AD) as discussed by the authors, and several compounds possess anti-cholinesterase activity in the order of micro and sub-micromolar.

TL;DR: A series of fourteen dispiropyrrolidines were synthesized using [3+2]-cycloaddition reactions and were screened for their antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv in HTS (High Throughput Screen).

TL;DR: A series of twelve dispiropyrrolidines synthesized using [3+2]-cycloaddition reactions screened for their antimycobacterial activity against M. tuberculosis H(37)Rv and INH resistant M.culosis strains using agar dilution method, four of them showed good activity.