A
Abhimanyu Singh
Researcher at Universiti Sains Malaysia
Publications - 7
Citations - 193
Abhimanyu Singh is an academic researcher from Universiti Sains Malaysia. The author has contributed to research in topics: Reverse transcriptase & Biology. The author has an hindex of 3, co-authored 4 publications receiving 157 citations.
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Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents
Mohamed Jawed Ahsan,Jeyabalan Govinda Samy,Habibullah Khalilullah,Md. Shivli Nomani,Pankaj Saraswat,Ramakant Gaur,Abhimanyu Singh +6 more
TL;DR: Among the title compounds, compound 4d showed pronounced activity against Mycobacterium tuberculosis H(37)Rv and isoniazid resistant M. tuberculosis (INHR-TB) with minimum inhibitory concentrations (MICs) 0.78μM and 1.52 μM, respectively.
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AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Mohamed Ashraf Ali,Rusli Ismail,Tan Soo Choon,Raju Suresh Kumar,Hasnah Osman,Natarajan Arumugam,Abdulrahman I. Almansour,Karthikeyan Elumalai,Abhimanyu Singh +8 more
TL;DR: Pyrrolothiazolyloxindole analogues share vital pharmacological properties, considered useful in Alzheimer's disease (AD) as discussed by the authors, and several compounds possess anti-cholinesterase activity in the order of micro and sub-micromolar.
Journal ArticleDOI
Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies
Abhimanyu Singh,Kalyan Das +1 more
TL;DR: The roles of structural biology in understanding and targeting HIV RT in the past three decades and the recent structural insights of RT are reviewed, using cryo-EM.
Journal ArticleDOI
AChE Inhibitor: A Regio‐ and Stereoselective 1,3‐Dipolar Cycloaddition for the Synthesis of Novel Substituted 5,6‐Dimethoxy Spiro[5.3′]‐oxindole‐spiro‐ [6.3′′]‐2,3‐dihydro‐1H‐inden‐1′′‐one‐7‐(substituted aryl)‐tetrahydro‐1H‐pyrrolo[1,2‐c][1,3]thiazole (IV).
Mohamed Ashraf Ali,Rusli Ismail,Tan Soo Choon,Raju Suresh Kumar,Hasnah Osman,Natarajan Arumugam,Abdulrahman I. Almansour,Karthikeyan Elumalai,Abhimanyu Singh +8 more
TL;DR: The most potent inhibitor of cholinesterase with an IC50 of 0.11 μmol/L was found in this article, where the IVg inhibitor was found to be the most effective inhibitor.
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Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine
Abhimanyu Singh,Brent De Wijngaert,Marc Bijnens,Kris Uyttersprot,Hoai Nguyen,Sergio E. Martinez,Dominique Schols,Piet Herdewijn,Christophe Pannecouque,Eddy Arnold,Kalyan Das +10 more
TL;DR: Cryo-EM structure determination strategy outlined in this study can be adapted to aid drug design targeting smaller and flexible proteins and have implications for understanding NNRTI drug resistance.