T
Tan Soo Choon
Researcher at Universiti Sains Malaysia
Publications - 90
Citations - 912
Tan Soo Choon is an academic researcher from Universiti Sains Malaysia. The author has contributed to research in topics: Ring (chemistry) & Benzimidazole. The author has an hindex of 17, co-authored 90 publications receiving 783 citations. Previous affiliations of Tan Soo Choon include Bharathiar University & Madurai Kamaraj University.
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Substituted spiro [2.3'] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.
Mohamed Ashraf Ali,Rusli Ismail,Tan Soo Choon,Yeong Keng Yoon,Ang Chee Wei,Suresh Pandian,Raju Suresh Kumar,Hasnah Osman,Elumalai Manogaran +8 more
TL;DR: Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors, and compounds 4k and 6k were the most potent inhibitors of the series.
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Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors.
Yeong Keng Yoon,Mohamed Ashraf Ali,Mohamed Ashraf Ali,Ang Chee Wei,Tan Soo Choon,Kooi Yeong Khaw,Vikneswaran Murugaiyah,Hasnah Osman,Vijay H. Masand +8 more
TL;DR: Of the 34 novel synthesized compounds, three benzimidazoles revealed AChE inhibition with IC50<10 μM, and the relationship between lipophilicity and the chemical structures as well as their limited structure-activity relationship was discussed.
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Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties
Yeong Keng Yoon,Mohamed Ashraf Ali,Ang Chee Wei,Amir Nasrolahi Shirazi,Keykavous Parang,Tan Soo Choon +5 more
TL;DR: Cell proliferation assay showed that compound 4j possessed good antitumor activity against three different types of cancer cells derived from colon, breast and blood-leukemia with cell viability of 40.0%, 53.0% and 27.2% respectively at 50 μM.
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AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Mohamed Ashraf Ali,Rusli Ismail,Tan Soo Choon,Raju Suresh Kumar,Hasnah Osman,Natarajan Arumugam,Abdulrahman I. Almansour,Karthikeyan Elumalai,Abhimanyu Singh +8 more
TL;DR: Pyrrolothiazolyloxindole analogues share vital pharmacological properties, considered useful in Alzheimer's disease (AD) as discussed by the authors, and several compounds possess anti-cholinesterase activity in the order of micro and sub-micromolar.
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Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.
Yeong Keng Yoon,Mohamed Ashraf Ali,Ang Chee Wei,Tan Soo Choon,Hasnah Osman,Keykavous Parang,Amir Nasrolahi Shirazi +6 more
TL;DR: Cell cytotoxicity assays showed that compound 5j possesses good antitumor activity against two different cancer cell lines derived from breast cancer (MCF-7 and MDA-MB-468).