J
Jean Francois Seitz
Researcher at Aix-Marseille University
Publications - 60
Citations - 16764
Jean Francois Seitz is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 26, co-authored 58 publications receiving 14362 citations. Previous affiliations of Jean Francois Seitz include University of the Mediterranean & Mayo Clinic.
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Journal ArticleDOI
Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more
TL;DR: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Journal ArticleDOI
Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer
Daniel J. Sargent,Silvia Marsoni,Geneviève Monges,Stephen N. Thibodeau,Roberto Labianca,Stanley R. Hamilton,Amy J. French,Brian Kabat,Nathan R. Foster,Valter Torri,Christine Ribic,Axel Grothey,Malcolm J. Moore,Alberto Zaniboni,Jean Francois Seitz,Frank A. Sinicrope,Steven Gallinger +16 more
TL;DR: Data support MMR status assessment for patients being considered for FU therapy alone and consideration of MMR status in treatment decision making and patient stratification by MMR status may provide a more tailored approach to colon cancer adjuvant therapy.
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Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much?
Sharlene Gill,Charles L. Loprinzi,Daniel J. Sargent,Stephan D. Thomé,Steven R. Alberts,Daniel G. Haller,Jacqueline Benedetti,Guido Francini,Lois E. Shepherd,Jean Francois Seitz,Roberto Labianca,Wei Chen,Stephen S. Cha,Michael P. Heldebrant,Richard M. Goldberg +14 more
TL;DR: Patients with high-risk resected colon cancer obtain benefit from FU-based therapy across subsets of age, sex, location, T stage, nodal status, and grade, which may improve patients' and physicians' understanding of the potential benefits of adjuvant therapy.
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A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients.
Daniel J. Sargent,Richard M. Goldberg,Stacy D. Jacobson,John S. Macdonald,Roberto Labianca,Daniel G. Haller,Lois E. Shepherd,Jean Francois Seitz,Guido Francini +8 more
TL;DR: In this article, a pooled analysis of individual patient data from seven phase 3 randomized trials (involving 3351 patients) in which the effects of postoperative fluorouracil plus leucovorin (five trials) or fluorourocil plus levamisole (two trials) were compared with surgery alone in patients with stage II or III colon cancer was performed.
Journal ArticleDOI
Disease-Free Survival Versus Overall Survival As a Primary End Point for Adjuvant Colon Cancer Studies: Individual Patient Data From 20,898 Patients on 18 Randomized Trials
Daniel J. Sargent,Harry S. Wieand,Daniel G. Haller,Richard Gray,Jacqueline Benedetti,Marc Buyse,Roberto Labianca,Jean Francois Seitz,Christopher J. O'Callaghan,Guido Francini,Axel Grothey,Michael J. O'Connell,Paul J. Catalano,Charles D. Blanke,David J. Kerr,Erin M. Green,Norman Wolmark,Thierry André,Richard M. Goldberg,Aimery de Gramont +19 more
TL;DR: It is suggested that DFS after 3 years of median follow-up is an appropriate end point for adjuvant colon cancer clinical trials of fluorouracil-based regimens, although marginally significant DFS improvements may not translate into significant OS benefits.