E
Edward Gane
Researcher at Auckland City Hospital
Publications - 414
Citations - 47176
Edward Gane is an academic researcher from Auckland City Hospital. The author has contributed to research in topics: Hepatitis C & Ribavirin. The author has an hindex of 81, co-authored 347 publications receiving 40725 citations. Previous affiliations of Edward Gane include University of Cambridge & Middlemore Hospital.
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Journal ArticleDOI
Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more
TL;DR: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Journal ArticleDOI
Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
Shiv Kumar Sarin,Manoj Kumar,George K. K. Lau,Zaigham Abbas,Henry Lik-Yuen Chan,Chien-Jen Chen,Ding-Shinn Chen,Huey-Ling Chen,Pei-Jer Chen,Rong-Nan Chien,Abdul Kadir Dokmeci,Edward Gane,J L Hou,Wasim Jafri,Jidong Jia,J. H. Kim,Ching-Lung Lai,Hon Cheung Lee,Seng Gee Lim,Chun-Jen Liu,Stephen Locarnini,M. Al Mahtab,Rosmawati Mohamed,Masao Omata,Jun Yong Park,Teerha Piratvisuth,Barjesh Chander Sharma,Jose D. Sollano,Fu-Sheng Wang,Lai Wei,Man-Fung Yuen,Shusen Zheng,Jia-Horng Kao +32 more
TL;DR: The final clinical practice guidelines and recommendations for the optimal management of chronic HBV infection are presented here, along with the relevant background information.
Journal ArticleDOI
Sofosbuvir for previously untreated chronic hepatitis C infection
Eric Lawitz,Alessandra Mangia,David L. Wyles,Maribel Rodriguez-Torres,Tarek Hassanein,Stuart C. Gordon,Michael Schultz,M. Davis,Zeid Kayali,K. Rajender Reddy,Ira M. Jacobson,Kris V. Kowdley,L. Nyberg,G. Mani Subramanian,Robert H. Hyland,Sarah Arterburn,Deyuan Jiang,John McNally,Diana M. Brainard,William T. Symonds,John G. McHutchison,Aasim Sheikh,Zobair M. Younossi,Edward Gane +23 more
TL;DR: In a single-group study of sofosbuvir combined with peginterferon-ribavirin, patients with predominantly genotype 1 or 4 HCV infection had a rate of sustained virologic response of 90% at 12 weeks.
Journal ArticleDOI
Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study
Sarah Blach,Stefan Zeuzem,Michael Manns,Ibrahim Altraif,Ann-Sofi Duberg,David H. Muljono,Imam Waked,Seyed M Alavian,Mei Hsuan Lee,Francesco Negro,Faisal Abaalkhail,Ahmed Abdou,Maheeba Abdulla,Antoine Abou Rached,Inka Aho,Ulus Salih Akarca,Imad Al Ghazzawi,Saad Al Kaabi,Faryal Al Lawati,Khalid Al Namaani,Youssif Al Serkal,Said A. Al-Busafi,Layla Al-Dabal,Soo Aleman,Abdullah S. Alghamdi,Abdulrahman Aljumah,Hamad Al-Romaihi,Monique Andersson,Vic Arendt,Perttu Arkkila,Abdullah M. Assiri,Oidov Baatarkhuu,Abate Bane,Ziv Ben-Ari,Colm Bergin,Fernando Bessone,Florian Bihl,Abdul Rahman Bizri,M. Blachier,Antonio Javier Blasco,Carlos E Brandão Mello,Philip Bruggmann,Cheryl Brunton,Filipe Calinas,Henry Lik-Yuen Chan,Asad Chaudhry,Hugo Cheinquer,Chien-Jen Chen,Rong-Nan Chien,Moon Seok Choi,Peer Brehm Christensen,Wan-Long Chuang,Vladimir Chulanov,Laura Cisneros,Mette Rye Clausen,Matthew E. Cramp,Antonio Craxì,E. A. Croes,Olav Dalgard,Jorge Daruich,Victor de Ledinghen,Gregory J. Dore,Manal H El-Sayed,Gül Ergör,Gamal Esmat,Chris Estes,Karolin Falconer,Elmoubashar Farag,Maria Lucia Gomes Ferraz,Paulo R. Ferreira,Robert Flisiak,Sona Frankova,Ivane Gamkrelidze,Edward Gane,Javier García-Samaniego,Akram Khan,Ilias Gountas,Adrian Goldis,Magnus Gottfredsson,Jason Grebely,Michael Gschwantler,Mario G. Pessoa,Jessie Gunter,Behzad Hajarizadeh,Omer Hajelssedig,Saeed Hamid,Waseem Hamoudi,Angelos Hatzakis,Sayed Himatt,Harald Hofer,Irena Hrstić,Yee Tak Hui,Béla Hunyady,Ramazan Idilman,Wasim Jafri,Rohani Jahis,Naveed Z. Janjua,Peter Jarcuska,Agita Jeruma,Jon G. Jonasson,Yasser Kamel,Jia-Horng Kao,Sabahattin Kaymakoglu,David Kershenobich,Jawad Khamis,Young Sik Kim,Loreta A. Kondili,Zaher Koutoubi,Mel Krajden,Henrik Krarup,Moon sing Lai,Wim Laleman,Wai-cheung C Lao,Daniel Lavanchy,Pablo Lázaro,Henri Leleu,Olufunmilayo A. Lesi,Laurentius A. Lesmana,Michael Li,Valentina Liakina,Young-Suk Lim,Boris Lukšić,Adam Mahomed,Matti Maimets,Mihály Makara,Abraham O. Malu,Rui Tato Marinho,Paul Marotta,Stefan Mauss,Muhammad S. Memon,Maria C Mendes Correa,Nahum Méndez-Sánchez,Shahin Merat,Ammal M. Metwally,Rosmawati Mohamed,Christophe Moreno,Fadi H. Mourad,Beat Müllhaupt,Kimberly Murphy,Helen Nde,Richard Njouom,Diana Nonković,Suzanne Norris,Solomon Obekpa,Stephen Oguche,S. Olafsson,Marian Oltman,Ogu Omede,CE Omuemu,Ohene Opare-Sem,Anne Øvrehus,Shirley Owusu-Ofori,Tsendsuren S. Oyunsuren,George V. Papatheodoridis,Ken Pasini,Kevork M. Peltekian,Richard Phillips,N. N. Pimenov,Hossein Poustchi,Nishi Prabdial-Sing,Huma Qureshi,Alnoor Ramji,Devin Razavi-Shearer,Kathryn Razavi-Shearer,Berhane Redae,Henk W. Reesink,Ezequiel Ridruejo,Sarah Robbins,Lewis R. Roberts,Stuart K. Roberts,William Rosenberg,Françoise Roudot-Thoraval,Stephen D. Ryder,Rifaat Safadi,Olga Sagalova,Riina Salupere,Faisal M. Sanai,Juan F.Sanchez Avila,Vivek A. Saraswat,Rui Sarmento-Castro,Christoph Sarrazin,Jonathan Schmelzer,Ivan Schréter,Carole Seguin-Devaux,Samir Shah,Ala I. Sharara,Manik Sharma,Anatoly Shevaldin,Gamal Shiha,William Sievert,Mark W. Sonderup,Kyriakos Souliotis,Danute Speiciene,Jan Sperl,Peter Stärkel,Rudolf E. Stauber,Catherine A.M. Stedman,Daniel Struck,Tung-Hung Su,Vana Sypsa,Soek Siam Tan,Junko Tanaka,Alexander J. Thompson,Ieva Tolmane,Krzysztof Tomasiewicz,Jonas Valantinas,Pierre Van Damme,Adriaan J. van der Meer,Ingo van Thiel,Hans Van Vlierberghe,Adriana Vince,Wolfgang Vogel,Heiner Wedemeyer,Nina Weis,Vincent Ws Wong,Cesar Yaghi,Ayman Yosry,Man-Fung Yuen,Evy Yunihastuti,Aasim Yusuf,Eli Zuckerman,Homie Razavi +221 more
TL;DR: The global estimate of viraemic HCV infections is lower than previous estimates, largely due to more recent prevalence estimates in Africa, and increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections.
Journal ArticleDOI
Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study
Patrick Marcellin,Edward Gane,Maria Buti,Nezam H. Afdhal,William Sievert,Ira M. Jacobson,Mary Kay Washington,George Germanidis,John F. Flaherty,Raul Aguilar Schall,Jeffrey D. Bornstein,Kathryn M. Kitrinos,G. Mani Subramanian,John G. McHutchison,E. Jenny Heathcote +14 more
TL;DR: In patients with chronic HBV infection, up to 5 years of treatment with tenofovir DF was safe and effective, and long-term suppression of HBV can lead to regression of fibrosis and cirrhosis.