Showing papers in "Ageing Research Reviews in 2022"

TL;DR: In this article , the authors summarize the key roles glucocorticoids, reactive oxygen species (ROS) and mitochondria play in mediating the relationship between psychological stress and telomere maintenance.

TL;DR: In this article, the authors summarize the key roles glucocorticoids, reactive oxygen species (ROS) and mitochondria play in mediating the relationship between psychological stress and telomere maintenance.

TL;DR: In this article , a review comprehensively expands on the roles of oxidative stress that are involved in the pathogenesis of Alzheimer's disease, and the vivid and easy-to-understand figures systematically clarify the connected roles of oxidative stress in AD and allow readers to further understand oxidative stress and AD.

TL;DR: A systematic review and meta-analysis of cross-sectional and longitudinal studies that investigated the association of frailty and/or sarcopenia with biomarkers as a primary or secondary outcome in adults aged 60 years and older was conducted in this paper .

TL;DR: A systematic review and meta-analysis of cross-sectional and longitudinal studies that investigated the association of frailty and/or sarcopenia with biomarkers as a primary or secondary outcome in adults aged 60 years and older was conducted in this article.

TL;DR: In this article , the authors synthesize what is known about the interaction between inflammaging and nutrition, focusing on the role of the Mediterranean diet, gut microbiota and calorie restriction (CR) in reducing systemic inflammation and improving clinical outcomes.

TL;DR: In this article , a review of the available evidence concerning the orchestrating role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease is summarized and discussed, and general considerations for future studies are highlighted.

TL;DR: The role of seven modifiable lifestyle factors (diet, smoking, alcohol consumption, physical activity, cognitive leisure activity, sleep, and meditation) in mitigating the impacts of age-related brain changes on cognition was examined in this paper .

TL;DR: In this article , the authors examined the dose-response relationship between overall and specific types of exercise with cognitive function in older adults and found no minimal threshold for the beneficial effect of exercise on cognition.

TL;DR: In this article , the authors present a review of the evolutionary mechanisms that give rise to pathogenic gene action and late-life disease, that integrates evolutionary (ultimate) and mechanistic (proximate) causes into a single explanation.

TL;DR: In this paper , the authors reviewed the function of IDO1-KYN-AhR signaling and discussed its activation with aging as an enhancer of the aging process, and showed that the activation of the IDO 1-Kynurenic acid pathway robustly increases with aging.

TL;DR: In this article , a comprehensive literature review was conducted to identify and discuss the role of mitochondrial miRNAs that regulate mitochondrial and synaptic functions, and how synapse damage and mitochondrial dysfunctions contribute to AD; the structure and function of synapse and mitochondria in the disease process.

TL;DR: In this paper, a comprehensive literature review was conducted to identify and discuss the role of mitochondrial miRNAs that regulate mitochondrial and synaptic functions, and how synapse damage and mitochondrial dysfunctions contribute to AD; the structure and function of synapse and mitochondria in the disease process.

TL;DR: In this paper , the authors extensively reviewed data on the currently explored biomarkers in terms of Alzheimer's disease pathology-specific and non-specific biomarkers and highlighted the recent developments in the diagnostic and theragnostic domains.

TL;DR: The early appearance and increased severity of age-associated disease among African American and low socioeconomic status (SES) individuals suggests that the factors contributing to the emergence of health disparities may also induce a phenotype of "premature aging" or "accelerated aging", which may proceed on a different trajectory than the overall population as discussed by the authors .

TL;DR: Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-related mitokine, but also as a key player in the aging process, being one of the most upregulated protein with age and associated with a variety of age-related diseases as mentioned in this paper .

TL;DR: The skeletal muscle might be the central integrator controlling both sarcopenia and inflammation in an aging biological system as mentioned in this paper , and over time, the ongoing and increasing presence of inflammatory cytokines, adipokines and myokines in the serum during aging and risk factor conditions may render the muscle more vulnerable to developing sarcopenias.

TL;DR: In this paper , the similarities and differences between exosomes and synaptic vesicles in their biogenesis, contents, and release are summarized, and the recent progress made in demonstrating the biological roles of exosome in regulating neurotransmission, and a modified model of neurotransmission is proposed.

TL;DR: In this paper , the authors discuss shared benefits and molecular pathways driving the protective effects of endurance exercise on various neurodegenerative diseases in animal models and in humans, including Amyotrophic Lateral Sclerosis, Alzheimer's, Parkinson's disease, and Huntington's disease.

TL;DR: In this article , the authors conducted a systematic review and meta-analysis to bridge the existing gap in literature about the association between depressive symptomatology, FOF, use of antidepressant therapy and falls, also identifying a possible effect of the study quality on the outcome.

TL;DR: Wang et al. as mentioned in this paper summarized the hallmarks of aging bone and osteocytes and discuss osteocytic mechanisms in age-related bone loss and impaired bone quality. But, detailed molecular mechanisms of osteocytes remain unclear.

TL;DR: In this paper , the implications of microglia and astrocytes in AD pathogenesis are discussed, and the mechanisms of therapeutic agents that exhibit anti-inflammatory effects against AD are discussed.

TL;DR: In this paper , the authors summarized the current understanding of SCFAs in hypertension, ischaemic reperfusion, myocardial infarction, atherosclerosis and heart failure.

TL;DR: In this article , the authors systematically searched PubMed and EMBASE, from inception to September 13th, 2021, for studies reporting the prevalence of frailty in atrial fibrillation patients.

TL;DR: In this paper , a review of the role of adult neurogenesis in neurodegenerative diseases is presented and the potential targets for interventions that could help in the fight against neuro degeneration and cognitive decline are discussed.

TL;DR: Parkinson's disease (PD) is the second most common age-associated neurodegenerative disorder and is characterised by progressive loss of dopamine neurons in the substantia nigra as mentioned in this paper .

TL;DR: In this article , the authors review and discuss experimental noninvasive brain stimulation (NiBS) applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleeprelated memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection.

TL;DR: In this article , the roles of noncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs are discussed. But, the authors focus on the noncoding transcripts play important roles in ageing that significantly increases the risk for CVD.

TL;DR: The role of clock genes in the development of Parkinson's disease was investigated in this article , where the authors summarized the findings of clock gene expression and epigenetic analyses in PD patients and animal models.

TL;DR: In this article, the expression pattern of mRNAs and miRNAs in exosomes derived from the AD and health mice was detected and the functions of differentially expressed mRNA and potential target genes of miRNA were determined by GO and KEGG analysis.