Showing papers in "Biotechnology & Biotechnological Equipment in 2020"
TL;DR: The available pharmacokinetic data from clinically relevant and excessive dosing studies indicate that the SARS-CoV-2 inhibitory concentrations are not likely to be attainable in humans.
Abstract: The broad-spectrum antiparasitic agent ivermectin has been very recently found to inhibit SARS-CoV-2 in vitro and proposed as a candidate for drug repurposing in COVID-19. In the present report the in vitro antiviral activity end-points are analyzed from the pharmacokinetic perspective. The available pharmacokinetic data from clinically relevant and excessive dosing studies indicate that the SARS-CoV-2 inhibitory concentrations are not likely to be attainable in humans.
92 citations
TL;DR: An overview of published studies for a better understanding of the anti-mutagenic potential of medicinal plants and the precise indications for the utilization of natural compounds as chemo-preventive agents is presented.
Abstract: This review presents an overview of published studies for a better understanding of the anti-mutagenic potential of medicinal plants and the precise indications for the utilization of natural compo...
24 citations
TL;DR: An effective and trustworthy traceability system contributes to improving food quality and safety and responds to consumers' demand for food provenance information as discussed by the authors. But traceability is not always easy.
Abstract: An effective and trustworthy traceability system contributes to improving food quality and safety and responds to consumers’ demand for food provenance information. Safe meat and its products are c...
24 citations
TL;DR: The accessions YTM15, Pulut Merah 3, Padi Randau, Ringan Bawang, DNJ128 and DV 107 can be potentially selected for development of new varieties for local cultivation and used as parents in further breeding programmes.
Abstract: Exploring the genetic aspects of germplasm using genotypic and phenotypic analysis is more reliable for the development of rice varieties that could lead to the attainment of food security. This is...
23 citations
TL;DR: A detailed integrative approach, which incorporates the innovative scientific achievements based on complex novel, precise and reliable analytical procedures and methods for qualitative and quantitative morphological, structural, spectral, chemical and biochemical analyses of the bio-precursors and the designed chitosan-carrier micro/nano-hybrid systems, is applied.
Abstract: The design and synthesis of biopolymer nano- and micro-formulations are a new trend with growing priority in scientific research and development in the fields of biomedicine, bioorganic/medicinal c...
22 citations
TL;DR: The present study employed sequence-related amplified polymorphism (SRAP) markers to characterize the genetic resources and genetic diversity within and between two groups of ten Bulgarian and five foreign lavender varieties and breeding lines.
Abstract: Lavender (Lavandula angustifolia Mill.) is an essential oil-bearing and medicinal plant of great economic and social importance to Bulgaria, which is the world largest producer of lavender oil nowa...
20 citations
TL;DR: Investigation of the possibility of biological removal of crude oil with the use of native bacterial strains, isolated from the shorelines of the Caspian Sea showed that isolate J3 had a better ability to degrade short and medium length n-alkanes in crude oil residues in comparison with the long length (C32–C35).
Abstract: This study was aimed at investigating the possibility of biological removal of crude oil with the use of native bacterial strains, isolated from the shorelines of the Caspian Sea. For this purpose,...
17 citations
TL;DR: The detection rate of lymphoma cells was higher than 96%, and the false detection rate was less than 13%, which is an improvement compared with the previously proposed results, and shows a potential of the proposed method in lymphoma diagnosis.
Abstract: Lymphoma has become the seventh most common cancer expected to occur and the ninth most common cause of cancer death in both males and females. However, pathological diagnosis as the main diagnosti...
16 citations
TL;DR: The results of the pilot study indicate that the presence and severity of the ocular complaints are dependent on the type of mask and the duration of usage, and all substances sustaining tear film balance and lipid layer thickness could be beneficial in ensuring the local defense mechanisms.
Abstract: The global pandemic of severe acute respiratory syndrome, COVID-19 affects the world’s economics, social and health systems and has a great impact on every person’s life. In an attempt to control t...
14 citations
TL;DR: This study compared the productivity of gamma-decalactone in batch cultures of two strains of Yarrowia lipolytica, wild strain W29 and its derived mutant MTLY40-2p, grown in flasks and a bioreactor to find the modified strain had a higher aroma synthesis capacity.
Abstract: Gamma-decalactone is an interesting flavuring compound with an intense oily-peachy aroma. It is commonly used in food and cosmetic industry. Biotechnological methods of its synthesis are based on t...
13 citations
TL;DR: In the present work, carrot chromosomes were saturated with sequence-specific markers, which constitute a physical map of the carrot genome, and these markers will serve as practical molecular tools for germplasm characterization, gene tagging and molecular breeding studies in this important crop species.
Abstract: Carrot (Daucus carota L.) is a versatile vegetable crop and the most economically important member of the Apiaceae family. While there are several important cultivated species in the family...
TL;DR: Analysis of the characteristics and functions of differentially abundant proteins in response to drought stress during the maize kernel-filling stage offers more insights into the molecular mechanisms underlying maize drought tolerance at the grain filling stage.
Abstract: Drought is a major abiotic stress factor that affects the yield of maize (Zea mays L.) during the grain filling period. Therefore, it is critical to reveal the molecular mechanisms underlying maize...
TL;DR: A considerable improvement has been made in the discovery of new signalling cascades and TFs, but to match the requirements of agriculture today, the authors must be capable of turning this knowledge into drought-tolerant transgenic crops in the field.
Abstract: Drought is one of the most critical environmental stresses adversely disturbing the yield and growth of plants worldwide. Acclimatizationto environmental constraints depends upon the activation of ...
TL;DR: The nanoconjugates form FC-Nps and Ag-NPs had minute particle size with increasing bioactivity as antimicrobial agents to control drug resistant bacterial pathogens, which recommends their further exploration for topical applications in biomedical sectors.
Abstract: Here we report the phycosynthesis of silver nanoparticles (Ag-NPs), using Codium capitatum extract, and the synthesis of fungal chitosan nanoparticles (FC-NPs), using extracted chitosan from Asperg...
TL;DR: This work identified two major B transport sequences in plants, NIP5;1 boric acid channel protein and BOR1 transporter, which demonstrated similar expression patterns although they act in different tissues, suggesting a common regulatory mechanism.
Abstract: Boron (B) is an essential plant micronutrient but studies regarding its transport are still limited to a few plants. This work identified two major B transport sequences in plants, NIP5;1 boric aci...
TL;DR: The results of this study indicated that mobile phone exposure during pregnancy could have an important potential to cause oxidative stress and DNA damage in cord blood and placenta.
Abstract: The aim of this study was to investigate the effects of radiofrequency radiation emitted from Wi-Fi systems and mobile phones on cord blood and placenta. The study included 149 pregnant women who w...
TL;DR: The resistance of cucumber to P. melonis is related to POX and PAL activities, but does not show relationship with PPO, SOD and CAT activities, as indicated by the results of this study.
Abstract: The hemibiotrophic oomycetes are significant threats to a wide range of Cucurbitaceae species, causing substantial losses of plant productions. Particularly, Phytophthora melonis Katsura evokes sev...
TL;DR: Comparative genomic analysis showed that there are genes encoding eight enzymes in the common genes of the four Serratia strains, highlighting the potential of the other three Serratian strains to degrade steroid estrogen.
Abstract: At present, the oestrogens detected in the environment have been classified as group 1 carcinogens by the World Health Organization. They have obvious effects on organisms at extremely low environm...
TL;DR: In this paper, the authors used the Zaoheibao fruit with rich rose-scented grapes as the main material to optimize the fermentation process of the wine and determined its composition in volatile aroma compounds.
Abstract: The “Zaoheibao” fruit with rich rose-scented grapes was used as the main material to optimize the fermentation process of “Zaoheibao” wine. Its composition in volatile aroma compounds was determine...
TL;DR: The results showed that the host diet and phylogeny both not only influence the bacterial communities, but also that NRPS gene clusters co-diversified with their gut microbiota, suggesting that potential NRPS natural products are hidden in the animal microbiome.
Abstract: The animal gut has a remarkable abundance of microbes. These microbes have strong potential for biosynthesis of promising drug candidates, and these small bioactive molecules often medicate importa...
TL;DR: This is the first detailed report of black yeast detected with potential antibacterial activity against various pathogenic microorganisms, and promise potential and interesting biotechnological tools to overcome the staggering problem of emerging antibiotic resistance among pathogenic bacteria.
Abstract: The adaptations that halophilic microorganisms have developed due to their extreme habitat, promote the production of active natural compounds with the potential to control microorganisms causing i...
TL;DR: In this paper, the authors explore whether there is a relationship between different electromagnetic radiations, such as extremely low-frequency magnetic field (ELF-MF), radiofrequency (RF) radiation and i...
Abstract: This study aims to explore whether there is a relationship between different electromagnetic radiations, such as extremely low-frequency magnetic field (ELF-MF), radiofrequency (RF) radiation and i...
TL;DR: The evidence strongly supported the natural antibacterial properties of the H. itama honey.
Abstract: The stingless bee Heterotrigona itama honey is generating interest among consumers due to unique antibacterial properties. Despite the substantial health benefits of this honey, its action mode of ...
TL;DR: Results from the first application of molecular-genetic analysis combined with conventional light microscopy for identification of cylindrospermopsin (CYN) producers in field phytoplankton samples from Bulgaria suggest that CYN remains stable in water after disappearance of the toxigenic species.
Abstract: This paper presents results from the first application of molecular-genetic analysis combined with conventional light microscopy (LM) for identification of cylindrospermopsin (CYN) producers in fie...
TL;DR: The present study provides a theoretical basis for the division, conservation, and utilization of walnut germplasm resources, and these findings can be applied in breeding programs to obtain high-quality cultivars of Juglans.
Abstract: The walnut is an excellent food product with abundant nutrients. However, the inference of its population structure has been hindered by the intricate phylogenetic relationships among Juglans speci...
TL;DR: This review focuses on the evidence base considering the therapeutic potential of metformin in NGT persons with MS representing a high-risk population for development of T2DM and CVD.
Abstract: With an increasing prevalence of metabolic syndrome (MS) early detection and timely management of cardiometabolic risk factors are crucial to prevent complications such as type 2 diabetes m...
TL;DR: In this paper, the authors utilized a renewable energy source, agricultural waste, in anaerobic digestion (AD) at appropriate conditions to obtain biogas and biomethane as an energy carrier.
Abstract: This study utilized a renewable energy source, agricultural waste, in anaerobic digestion (AD) at appropriate conditions to obtain biogas and biomethane as an energy carrier. Maize stalks underwent...
TL;DR: ZW-10 can be used as a potential biological agent in the control of rice blast by showing significant activity against M. oryzae and having good acidity resistance.
Abstract: Rice blast is one of the most destructive diseases of rice and is caused by the infection with rice blast fungus, Magnaporthe oryzae. In the present study, we obtained 12 bacterial isolates from Si...
TL;DR: Genotypes found in this article can be applied to the construction of temperature-sensitive engineering strains and the regulation of cell permeability.
Abstract: A temperature-sensitive mutant of Corynebacterium glutamicum is widely used as the fermentation strain in L-glutamate industrial production. Rapid synthesis of L-glutamate in this type of strain ca...
TL;DR: The expression of PwNAC genes, including PWNAC11, 24, 36, 38, 45, 47, 51 and 52, was greatly induced not only by salt stress but also by drought treatment, suggesting that these genes are involved in both salt and drought stress resistance in P. wilsonii.
Abstract: Picea wilsonii is widely used for a forestation and landscaping in China. However, the molecular mechanisms underlying abiotic stress tolerance in this species remain elusive. In this study...