Showing papers in "Cancer Letters in 1984"

TL;DR: Calcium soap formation of dietary fatty acids may be one natural mechanism by which colon epithelium cells are protected hence reducing the impact of dietary fat on carcinogenesis for this organ.

TL;DR: Hematoporphyrin (5 mg/ml), administered intravenously to tumor-bearing patients, becomes associated with different serum proteins, including lipoproteins (mainly HDL), globulin and albumin, which appears to be particularly stable probably owing to the hydrophobic nature of hematopomorphyrin.

TL;DR: The micronucleus test on exfoliated cells has been successfully used to recognize population groups at an elevated risk for cancer of the oral cavity or urinary bladder and pinpoint the site within an organ from which most carcinomas will develop.

TL;DR: An examination of crystallographic data has indicated that the structure/activity relationship for diorganotin dihalide complexes is different from that of other metal dihalides, in that the Sn-N bond lengths appear to determine the antitumour activity.

TL;DR: Skin tumor development was dependent upon 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion whereas lung tumor induction was not, and previous observations of carcinogenic activity of acrylamide in the skin of SENCAR mice and lungs of strain A/J mice to a third strain of mouse, the ICR-Swiss.

TL;DR: Results show that sodium erythorbate and ethoxyquin promote urinary bladder carcinogenesis, while ascorbic acid does not.

TL;DR: Cocultures of human fibroblasts with 3 different human tumor cell lines exhibited high levels of collagenase activity against type I collagen compared to individual cultures of each cell type, indicating that human tumor cells secrete a factor(s) which stimulates collagenase production by human fib roblasts.

TL;DR: Piroxicam, a non-steroidal anti-inflammatory agent, was administered in the feed to rats which had been inoculated intra-rectally with N-methylnitrosourea (MNU) and showed a significant reduction of intestinal tumors when examined 5 months later.

TL;DR: The induction of edema in the mouse ear has been established as a reliable in vivo assay for tumor promoting compounds and for inhibitors of tumor promotion.

TL;DR: A diet deficient in choline and methionine, known to produce hepatocellular carcinoma in the absence of any added chemical carcinogen, induced lipid peroxidation in the nuclear fraction of the liver when fed to male Fischer 344 rats.

TL;DR: The peroxisome proliferators Wy-14,643, BR-931, nafenopin and ciprofibrate were tested in the primary hepatocyte culture-unscheduled DNA synthesis assay and in the Ames Salmonella microsome mutagenicity assay.

TL;DR: Findings suggest that lipoproteins may be useful markers for tumours as well as carriers for cytotoxic drugs to target tissues in vivo.

TL;DR: The viability of human breast cancer cells (cell lines MCF-7 and MDA-MB 231) was inhibited in vitro in a dose-dependent manner by selenium supplementation, however, a normal diploid human cell line (MRC-5) was relatively resistant to seenium supplementation.

TL;DR: It is suggested that both AAI as well as AAII can be used in further studies to elucidate the metabolism of aristolochic acid.

TL;DR: Six oxidizing chemicals were tested for promoting and complete carcinogenic activities in skin carcinogenesis using female Sencar mice and Benzoyl peroxide was found to be a potent promoter as reported previously.

TL;DR: Evidence is presented that the growth of carcinogen-induced tumors can be inhibited by tetracyclines, and it is shown that the development in the cheek pouch of the Syrian hamster of a transplantable hypernephroma from human origin can be strongly retarded by termacycline.

TL;DR: The results collectively suggest that didemnin B acts differently, at least in part, from other depsipeptide antibiotics and its biological effect is primarily mediated through its inhibition of protein synthesis and to a lesser extentIts inhibition of DNA synthesis.

TL;DR: Ptaquiloside (PT) which induced mammary cancer in female CD rats and rho-hydroxystyrene glycosides were isolated from this fraction.

TL;DR: The photosensitivity of freshly dissociated R3230AC mammary adenocarcinoma cells was examined and mitochondrial membrane enzymes associated with the mitochondrial membrane demonstrated a very rapid and more marked inhibition of activities after treatment with hematoporphyrin derivative and exposure to light in vitro, suggesting that the mitochondria are an early-affected and important intracellular site for Hpd photosensitization.

TL;DR: These compounds, when given after initiation of many organs by a single carcinogen, exert an influence on the site of tumor development by, as yet unknown, organotropic modifying effects.

TL;DR: The data suggest that antioxidative mechanisms of patients with gynaecological cancer may be defective and that treatment with selenium and vitamin E results in changes of biochemical factors related to lipid peroxidation.

TL;DR: Significant increase in the number of SCEs was observed in the treated groups, and this increase, although dose-dependent, was not dependent upon the duration of exposure.

TL;DR: Thecondensate emitted from a coal fired residential furnace as well as the reconstituted condensate combining all fractions, provoked local tumors after repeated application to the dorsal skin of mice, showing a clear cut dose-response relationship.

TL;DR: NMDHP was the least potent of the 4 carcinogens, and induced lung tumors, neoplastic nodules in the liver, a few esophageal tumors and a few nasal cavity tumors, but after a long induction time.

TL;DR: The present results show that styrene oxide is a direct-acting carcinogen producing benign and malignant tumours of the forestomach.

TL;DR: Neutral gossypol solution injected peritoneally into NMRI mice preimplanted with Ehrlich ascites tumour cell, at a dose of 25-100 micrograms/mouse per day, lengthened the number of survival days of the hosts.

TL;DR: The NK cell cytotoxic response was enhanced in both the low and medium dose selenium-exposed groups and treatment with cyclophosphamide resulted in a significant reduction of splenic NK Cell cytotoxicity.

TL;DR: The results suggest a defect in removal of eicosanoids from large tumours, and the capacity of tumour microsomes to synthesize PGs in vitro was inversely related to tumour size.

TL;DR: Comparison of this data with that obtained from the same mouse strain using diesel exhaust particulate extracts containing 1-nitropyrene and its nitrated products indicate that these nitrated polynuclear aromatics do not significantly contribute to the mouse skin tumorigenic activity of diesel exhaust particle extracts.

TL;DR: Comparative induction of unscheduled DNA synthesis (UDS) and morphological transformation in the same cell system (Syrian hamster embryo fibroblasts) are indicative of a genotoxic mechanism for the carcinogenic actions of HCBD and PCBA.