Chinese bulletin of Life sciences 

About: Chinese bulletin of Life sciences is an academic journal. The journal publishes majorly in the area(s): Gene & Stem cell. Over the lifetime, 459 publications have been published receiving 1624 citations.

Database resources of the national center for biotechnology information and its application

Abstract: The National Center for Biotechnology Information(NCBI) is a big system of bioinfor-matics It provides data analysis and retrieval and resources that operate on the data in GenBank and a variety of other biological data made available through NCBI's Web site NCBI data retrieval resources include Entrez, PubMed, LocusLink and the Taxonomy Browser Data analysis resources include BLAST, Electronic PCR, OrfFinder, etc It is a very important biological resources for us to do research

C-type lectins

Abstract: C-type lectins are Ca2+-dependent glycan-binding proteins and share primary and secondary structural homology in their carbohydrate-recognition domains(CRDs).However,many members of this family are recently identified not to bind carbohydrates and have evolved to recognize non-sugar ligands such as proteins and lipids.The large family of C-type lectins has an important role in the physiological functions and pathological processes including immune homeostasis,immune defenses,and immune surveillance and so on.In this short review,we summarize the structure of C-type lectin domain,the classification of C-type lectins and their role in the immune system.

Status of harmful algal blooms and related research activities in China

Abstract: In this paper, we summarized history, main events and present status of HAB(harmful algal blooms) along Chinese coast. It showed that HAB in China increased in its frequency and scale, in number of HAB species, in percentage of toxic HAB events and the degree of damages to marine environment and economy. The cause of frequent,HAB occurrence in China was discussed. We also reviewed HAB research progress in the process of HAB formation, culturing technique, taxonomy, physiology, ecology and life cycle, algal toxin distribution and production, modeling, prevention and treatment. Suggestions in HAB research and management in the future were also proposed.

Control of macrophage activation and function by PPARs

Abstract: Macrophage,a key component of the innate defense against pathogens,participates in the initiation and resolution of inflammation,and in the maintenance of tissues.These diverse functions of macrophages are executed via distinct activation states,ranging from classical to alternative to deactivation.The dysregulation of macrophage activation is pathogenically linked to various metabolic,inflammatory and immune disorders.Regulatory proteins controlling macrophage activation have emerged as important new therapeutic targets.Here,the mechanisms by which peroxisome proliferator-activated receptors(PPARs) transcriptionally regulate macrophage activation in disease states are reviewed.

FOXP3~+ regulatory T cells

Abstract: Regulatory T cells (Tregs) play a fundamental role in maintaining immune homeostasis in vivo Treg cells have been actively involved in controlling major human diseases including autoimmune diseases, infectious diseases, allergic diseases and the immune surveillance of tumors The forkhead family transcription factor FOXP3 is a master regulator of natural Treg development and function The underlying mechanism by which FOXP3 functions in Treg cells is dependent not only on FOXP3 transcription and expression, but also on FOXP3 posttranslational modification and transcriptional complex ensemble with other cofactors including protein posttranslational modification enzymes Understanding the FOXP3 biochemistry and its dynamic ensemble with enzymatic cofactors will lead to novel therapeutic approaches for treating autoimmunity, infection, allergy, organ transplantation and cancer immunotherapy