Chinese Journal of Industrial Medicine 

About: Chinese Journal of Industrial Medicine is an academic journal. The journal publishes majorly in the area(s): Noise & Pneumoconiosis. Over the lifetime, 140 publications have been published receiving 191 citations.

Study of effects of lead acetate on reproductive function in male mice

Abstract: Male mice were orally administered with lead acetate of10mg/kg,20mg/kg and40mg/kg,respectively,via gastric tube once daily for35days,consecutively.Activities of glucose-6-phosphate dehydrogenase(G-6-PD),acid phosphatase(ACP),β-glycosidase(β-G),lactic acid dehydrogenase(LDH)and lactic acid dehydrogenase isoenzyme(LDHx)in the serum and testis ho-mogenate of male mice were determined with spectrophotometry and their fertility was measured with a standard method.Their testis and epididymis were examined histopathologically.Results showed that insemination rate in male mice,pregnancy rate in female mice,av-erage number of live birth of mice per nest and activities ofβ-G and LDHx in testis homogenate decreased with the increase of dose of lead acetate,as compared to the control mice,while stillbirth rate and embryo resorption rate increased with dose of lead acetate,in a significant dose-response pattern,as compared with the negative control group(P0.05),with coefficients of regression of-0.412,-0.420,-0.537,-0.538,-0.617,0.542and0.535,respectively.While,mating rate in male mice,activities of G-6-PD,ACP and LDH in the serum and testis homogenate in the rats exposed to40mg/kg of lead acetate were significantly different from those in the negative control group(P0.01or P0.05),indicating that fertility in male mice could be damaged by exposed to≥20mg/kg of lead acetate.

Research progress on carcinogenicity of nickel and its compounds

Abstract: Nickel,as one of the most abundant elements in earth's crust,is widely distributed in environment and used in industrial production,therefore extensively permeates to human daily life.Since the elevated lung cancer incidence among the nickel-refinery workers in Clydach,South Wales was reported,the carcinogenicity associated with the exposure of nickel and its compounds greatly interested public attention and the study has been done deeply and deeply.In this paper,the recent epidemiological and toxicological evidences about the carcinogenicity of nickel and its compounds exposure were reviewed for offering more comprehensive assessment on it.

Effect of environmental exposure to cadmium on pregnancy outcome and fetal growth

Abstract: Objective To evaluate the potential effect of environmental exposure to cadmium on pregnancy outcome and fetal growth.Method Pregnant women were selected from cadmium-polluted area and control area at Daye City in Hubei Province between November2002and January2003,the data such as their age,gestational age,pregnancy history,and life style etc.were obtained from questionnaire interview.The gravidas were examined for height and weight before delivery,and the newborns were examined for Apgar score,birth height and birth weight;the whole blood of gravidas,the cord blood and the placenta were collected for the detec-tion of cadmium levels by inductively coupled plasma emission mass spectroscopy.The incidences of premature birth(gestational age≤37weeks),neonatal asphyxia,birth height and weight of neonates were compared between gravidas from cadmium-polluted area and control area.Result The incidences of premature birth and neonatal asphyxia in the gravidas from cadmium-polluted area were20.8%and29.2%respectively,which were10.0%and15.0%respectively in the gravidas from control area but there was no significant dif-ference between those two groups.While the birth height of neonates from cadmium-polluted area(47.88±4.15)cm was lower than that of control area(50.65±2.41)cm,(P0.01).Multiple linear regressions analysis indicated that cord blood cadmium level was significantly negatively associated with birth height.Each log-increase of cadmium level in cord blood was associated with2.10cm de-crease in birth height of neonate.Conclusion Environmental exposure to cadmium could significantly lower neonatal birth height.