Chongqing Medicine 

About: Chongqing Medicine is an academic journal. The journal publishes majorly in the area(s): Cell & Apoptosis. Over the lifetime, 198 publications have been published receiving 318 citations.

Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication.

Abstract: Objective To determine whether sequential therapy eradicates Helicobactor pylori(HP) infection better than standard triple-drug therapy for adults with chronic gastritis and peptic ulcer.Methods 102 patients with HP positive were randomly divided into two groups.50 patients received 10d sequential therapy [esomeprazole(20mg twice daily) plus amoxicillin(1 000mg twice daily) for the first 5d,followed by esomeprazole(20mg),clarithromycin(500mg) and tinidazole(500mg) twice daily for the remaining 5d].52 patients received 7d triple therapy[esomeprazole(20mg),clarithromycin(500mg) and amoxicillin 1 000mg twice daily].Results The eradication rate of 10d sequential therapy was 92.00%,and that of control group was 76.92%.The difference between two groups was significant(P0.05).Conclusion 10d sequential therapy achieves a higher eradication rate than standard triple therapy for the first time in adults.

Maternal and neonatal individual risks and benefits associated with caesarean delivery

Abstract: Objective To assess the risks and benefits associated with caesarean delivery.Methods The retrospectively analysis was performed on 900 cases of pregnant women who delivery in the first people′s hospital of Jingmen from July 2008 to July 2009.Results Women undergoing caesarean delivery had an increase risk of severe maternal morbidity compared with women undergoing vaginal delivery.The risk of antibiotic treatment after delivery for women having either type of caesarean was five times that of women having vaginal deliveries,but caesarean delivery had a large protective effect on the incidence of third and fourth degree perineal laceration.There was a trend towards a reduced odds ratio for fetal death with elective caesarean,after adjustment for possible confounding variables and gestational age.With cephalic presentation,however,independent of possible confounding variables and gestational age,elective and intrapartum caesarean increased the risk for a stay of seven or more days in neonatal intensive care[2.1(1.75-2.55)and 1.93(1.63-2.79),respectively],and the risk of neonatal mortality up to hospital discharge[1.66(1.26-2.2)and 1.99(1.51-2.63),respectively],which remained higher even after exclusion of all caesarean deliveries for fetal distress.Such increased risk was not seen for breech presentation.Conclusion Caesarean delivery has a large protective effect on the incidence of third and fourth degree perineal laceration,and it independently reduces overall risk in breech presentations and risk of intrapartum fetal death in cephalic presentations,but increases the risk of severe maternal and neonatal morbidity and mortality in cephalic presentations.

Comparison and analysis of the detection performance of six new coronavirus nucleic acid detection reagents

Abstract: Objective To compare and analyse the detection performance of different 2019-new coronavirus (2019-nCoV) nucleic acid detection kits, in order to provide references for laboratory. Methods Six kinds of domestic reagents (A—F reagent) were selected for parallel detection of a series of samples from one patient in this hospital whose 2019-nCoV nucleic acid result was confirmed weakly positive. The samples were taken at three different times, the RNAs were extracted and amplified, and two parallel tests were performed each time by use of these six kits. The detection performance was compared according to the results of each kit. Results The three parallel test results (ORF1ab and N gene) of C and F reagents were positive, the results of D reagent showed the N gene was not detected, and the results of A, B, E reagents showed the ORF1ab gene was not detected sometimes. The reproducibility of in-batch detections by C reagent was the best, and the CT values of F reagents (N and ORF1ab), E reagents (ORF1ab) and A reagents (ORF1ab) showed changes in trend. Conclusion There are differences in the detection ability of six 2019-nCoV nucleic acid detection reagents for weakly positive samples, and the accuracy, sensitivity and reproducibility of some reagents are not good. There is an urgent need to further optimize and improve their performance in order to better meet the needs of large-scale screening. Key words: 2019 new coronavirus; nucleic acid detection; reagent kits, diagnostic; performance comparison

Investigation and analysis of the psychological status of the clinical nurses in a class A hospital facing the novel coronavirus pneumonia

Abstract: Objective To investigate the psychological status of clinical nurses in a class A hospital facing the novel coronavirus pneumonia (NCP), in order to provide effective psychological and social intervention. Methods A total of 867 clinical nurses were randomly selected from the Mianyang Central Hospital. The general information questionnaire, standard self-assessment anxiety scale (SAS) and crisis intervention classification assessment scale (TAF) were used to conduct self-assessment questionnaire survey. Then the data were analyzed by the SPSS22.0 software. Results 38.8% of the nurses had a low risk of infection, 18.0% of them had a medium risk, 29.6% had a medium high risk, and 13.6% had a high risk. The SAS scores of clinical nurses in this hospital were statistically significant different, compared with the Chinese norm value (P<0.05). The difference between TAF score and the degree of crisis response of nursing students in SARS period was statistically significant (P<0.05). The majority of clinical nurses had less crisis response to NCP, with 80.7% of them suffered mild cognitive, emotional and behavioral damage, and only 2.0% suffered severe damage. Analysis of related factors showed that department, self-test risk of infection, length of service had significant influence on SAS and TAF scores of clinical nurses (P<0.05). Conclusion During the period of NCP prevalence, no obvious anxiety and crisis reaction among clinical nurses is found in the third grade hospital. However, the psychological changes of clinical nurses with middle-age, from key epidemic prevention departments and in high risk of self-test infection are more likely to produce anxiety and crisis reaction. Therefore, appropriate and timely psychological intervention should be given. Key words: novel coronavirus pneumonia; clinical nurse; psychological status